DegronMD

Uniprot ID: Q6ZVD8

Source protein: PH domain leucine-rich repeat-containing protein phosphatase 2

Source gene: PHLPP2

Class: DEG_SCF_FBW7_1

Location: 1067:1073

E3 ligase: FBXW7

DEGRON score: 0.9597

ASA_SCORE: 72.3714

COIL: 0.8654

CONS_SCORE: 0.4412

DSS_SCORE: 0.5967

HELIX: 0.0836

FCONS_SCORE: 0.9897

RIG_SCORE: 0.619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1073G	TCGA-AD-6895	COAD	TCGA	PATPSSS	DEG_SCF_FBW7_1	0.6993
p.S1073G	DO8938	COAD	ICGC	PATPSSS	DEG_SCF_FBW7_1	0.6993
p.A1077D	TCGA-B5-A0JR	UCEC	TCGA	PATPSSS	DEG_SCF_FBW7_1	0.2222
p.A1077D	DO41791	UCEC	ICGC	PATPSSS	DEG_SCF_FBW7_1	0.2222
p.P1065H	DO233612	GACA	ICGC	PATPSSS	DEG_SCF_FBW7_1	0.2778
p.P1070Q	DO229038	LICA	ICGC	PATPSSS	DEG_SCF_FBW7_1	0.7035
p.A1064D	DO229045	LICA	ICGC	PATPSSS	DEG_SCF_FBW7_1	0.25
p.E1079D	SIDM00736	Non-Cancerous	GDSC	PATPSSS	DEG_SCF_FBW7_1	0.1667
p.M1064L	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPSSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SCF_FBW7_1	1067:1073	PATPSSS	FBXW7	0.9597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons