DegronMD

Uniprot ID: P56715

Source protein: Oxygen-regulated protein 1

Source gene: RP1

Class: DEG_COP1_1

Location: 201:209

E3 ligase: COP1

DEGRON score: 0.6862

ASA_SCORE: 66.2444

COIL: 0.7328

CONS_SCORE: 0.7849

DSS_SCORE: 0.1538

HELIX: 0.0898

FCONS_SCORE: 0.9832

RIG_SCORE: 0.805

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L209R	TCGA-38-4631	LUAD	TCGA	TDGRRVPSL	DEG_COP1_1	0.8428
p.L209R	DO24970	LUAD	ICGC	TDGRRVPSL	DEG_COP1_1	0.8428
p.R204M	TCGA-5M-AAT6	COAD	TCGA	TDGRRVPSL	DEG_COP1_1	0.7521
p.R204M	DO223703	COAD	ICGC	TDGRRVPSL	DEG_COP1_1	0.7521
p.R193H	TCGA-A5-A2K5	UCEC	TCGA	TDGRRVPSL	DEG_COP1_1	0.1111
p.R193H	TCGA-AJ-A3BH	UCEC	TCGA	TDGRRVPSL	DEG_COP1_1	0.1111
p.R193H	DO41638	UCEC	ICGC	TDGRRVPSL	DEG_COP1_1	0.1111
p.R193H	DO41379	UCEC	ICGC	TDGRRVPSL	DEG_COP1_1	0.1111
p.L209I	TCGA-BF-A5EQ	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	0.6063
p.L209I	DO219452	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	0.6063
p.G203R	TCGA-D3-A8GK	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	0.6457
p.G203R	DO50286	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	0.6457
p.G203R	SIDM01608	Endometrial Carcinoma	GDSC	TDGRRVPSL	DEG_COP1_1	0.6457
p.G203R	SIDM01442	Glioma	GDSC	TDGRRVPSL	DEG_COP1_1	0.6457
p.G203R	ACH-000807	Brain Cancer	CCLE	TDGRRVPSL	DEG_COP1_1	0.6457
p.G203R	ACH-000990	Endometrial/Uterine Cancer	CCLE	TDGRRVPSL	DEG_COP1_1	0.6457
p.G203E	TCGA-D9-A6EC	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	0.6087
p.G203E	DO220901	MELA	ICGC	TDGRRVPSL	DEG_COP1_1	0.6087
p.G203E	DO229453	SKCA	ICGC	TDGRRVPSL	DEG_COP1_1	0.6087
p.G203E	DO50291	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	0.6087
p.Q192K	TCGA-MI-A75I	LIHC	TCGA	TDGRRVPSL	DEG_COP1_1	0.0833
p.Q192K	DO49712	LIHC	ICGC	TDGRRVPSL	DEG_COP1_1	0.0833
p.I213F	TCGA-NC-A5HN	LUSC	TCGA	TDGRRVPSL	DEG_COP1_1	0.2222
p.I213F	DO52025	LUSC	ICGC	TDGRRVPSL	DEG_COP1_1	0.2222
p.R193C	TCGA-QK-A6IG	HNSC	TCGA	TDGRRVPSL	DEG_COP1_1	0.1111
p.R193C	DO233882	GACA	ICGC	TDGRRVPSL	DEG_COP1_1	0.1111
p.R193C	DO50002	HNSC	ICGC	TDGRRVPSL	DEG_COP1_1	0.1111
p.V212M	TCGA-V5-A7RE	ESCA	TCGA	TDGRRVPSL	DEG_COP1_1	0.25
p.V212M	TCGA-YG-AA3O	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	0.25
p.V212M	DO51299	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	0.25
p.I213T	DO50354	ESAD	ICGC	TDGRRVPSL	DEG_COP1_1	0.2222
p.V219M	DO233726	GACA	ICGC	TDGRRVPSL	DEG_COP1_1	0.0556
p.M191I	DO228986	LICA	ICGC	TDGRRVPSL	DEG_COP1_1	0.0556
p.M191I	DO229029	LICA	ICGC	TDGRRVPSL	DEG_COP1_1	0.0556
p.V212L	DO229009	LICA	ICGC	TDGRRVPSL	DEG_COP1_1	0.25
p.A200T	DO48682	LIRI	ICGC	TDGRRVPSL	DEG_COP1_1	0.3056
p.R205K	DO220877	MELA	ICGC	TDGRRVPSL	DEG_COP1_1	0.6126

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TDGRRVPSL

Degron related mutations and impact score

Drug responses associated with RP1 mutations

All proteins holding degron of TDGRRVPSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56715	Oxygen-regulated protein 1	DEG_COP1_1	201:209	TDGRRVPSL	COP1	0.6862	More...