DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FQTVWATV
Uniprot ID:
Q9BY89
Source protein:
Uncharacterized protein KIAA1671
Source gene:
KIAA1671
Class:
DEG_MDM2_SWIB_1
Location:
607:614
E3 ligase:
MDM2
DEGRON score:
0.5226
ASA_SCORE:
76.4
COIL:
0.5593
CONS_SCORE:
0.5899
DSS_SCORE:
0.4211
HELIX:
0.191
FCONS_SCORE:
1.1427
RIG_SCORE:
0.8193
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H617Y
DO224721
COCA
ICGC
FQTVWATV
DEG_MDM2_SWIB_1
0.25
p.V599I
SIDM00855
Other Sarcomas
GDSC
FQTVWATV
DEG_MDM2_SWIB_1
0.1111
p.V599I
G-402
soft_tissue
COSMIC
FQTVWATV
DEG_MDM2_SWIB_1
0.1111
Drug responses associated with KIAA1671 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FQTVWATV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BY89
Uncharacterized protein KIAA1671
DEG_MDM2_SWIB_1
607:614
FQTVWATV
MDM2
0.5226
More...