DegronMD

Uniprot ID: Q9H2Y7

Source protein: Zinc finger protein 106

Source gene: ZNF106

Class: DEG_SCF_SKP2-CKS1_1

Location: 439:446

E3 ligase: SKP2,CSK1

DEGRON score: 0.8293

ASA_SCORE: 106.1375

COIL: 0.8328

CONS_SCORE: 0.293

DSS_SCORE: 0.7394

HELIX: 0.1351

FCONS_SCORE: 0.8463

RIG_SCORE: 0.6237

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L455F	TCGA-18-3409	LUSC	TCGA	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L455F	DO26444	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.P456S	TCGA-EE-A2MJ	SKCM	TCGA	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P456S	DO38099	SKCM	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T434A	DO230309	COCA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P438H	DO233855	GACA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E454G	DO22237	LGG	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P444T	DO228948	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P456Q	DO229018	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Q440K	DO229019	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.5833
p.Q440K	DO229045	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.5833
p.Q436K	DO229045	LICA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.P453S	DO230950	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P453S	DO224638	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S452F	DO26444	LUSC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.P438L	DO220884	MELA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S452P	DO219881	SKCA	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.V443A	DO42023	UCEC	ICGC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.6936
p.S449L	SIDM00359	Colorectal Carcinoma	GDSC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.S449L	ACH-000565	Colon/Colorectal Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.S449L	RCM-1	large_intestine	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.25
p.T430S	ACH-000178	Pancreatic Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.T430S	Hs766T	pancreas	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K450T	ACH-000898	Gastric Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.2222
p.S441R	ACH-000991	Colon/Colorectal Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S441R	SNU-81	large_intestine	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.7427
p.S452Y	ACH-001328	Skin Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.S452Y	A431	skin	COSMIC	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.6111
p.L435I	ACH-001513	Cervical Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E437Q	ACH-001842	Bile Duct Cancer	CCLE	EQEHTPNK	DEG_SCF_SKP2-CKS1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EQEHTPNK

Degron related mutations and impact score

Drug responses associated with ZNF106 mutations

All proteins holding degron of EQEHTPNK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2Y7	Zinc finger protein 106	DEG_SCF_SKP2-CKS1_1	439:446	EQEHTPNK	SKP2,CSK1	0.8293	More...