DegronMD

Uniprot ID: Q9H2Y7

Source protein: Zinc finger protein 106

Source gene: ZNF106

Class: DEG_SPOP_SBC_1

Location: 1306:1310

E3 ligase: SPOP

DEGRON score: 0.9873

ASA_SCORE: 52.72

COIL: 0.5838

CONS_SCORE: 0.3563

DSS_SCORE: 0.5426

HELIX: 0.2736

FCONS_SCORE: 1.0141

RIG_SCORE: 0.7184

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1310F	TCGA-06-5416	GBM	TCGA	ACTSS	DEG_SPOP_SBC_1	0.7982
p.S1310Y	TCGA-AX-A0J0	UCEC	TCGA	ACTSS	DEG_SPOP_SBC_1	0.712
p.P1297A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ACTSS	DEG_SPOP_SBC_1	0.0833
p.P1297A	SIDM01689	B-Lymphoblastic Leukemia	GDSC	ACTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1306:1310	ACTSS	SPOP	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons