DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_SCF_FBW7_1

Location: 1848:1855

E3 ligase: FBXW7

DEGRON score: 0.9938

ASA_SCORE: 85.3

COIL: 0.9476

CONS_SCORE: 0.2437

DSS_SCORE: 0.7134

HELIX: 0.0318

FCONS_SCORE: 1.1801

RIG_SCORE: 0.6195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1861Y	TCGA-AP-A1DK	UCEC	TCGA	LTPTPDSS	DEG_SCF_FBW7_1	0.1667
p.S1861Y	DO42033	UCEC	ICGC	LTPTPDSS	DEG_SCF_FBW7_1	0.1667
p.P1862H	TCGA-BK-A13B	UCEC	TCGA	LTPTPDSS	DEG_SCF_FBW7_1	0.1389
p.P1862H	DO40825	UCEC	ICGC	LTPTPDSS	DEG_SCF_FBW7_1	0.1389
p.P1852L	TCGA-GN-A4U5	SKCM	TCGA	LTPTPDSS	DEG_SCF_FBW7_1	0.7582
p.P1852L	DO51257	SKCM	ICGC	LTPTPDSS	DEG_SCF_FBW7_1	0.7582
p.L1839R	SIDM00950	Pancreatic Carcinoma	GDSC	LTPTPDSS	DEG_SCF_FBW7_1	0.0833
p.L1839R	ACH-000243	Pancreatic Cancer	CCLE	LTPTPDSS	DEG_SCF_FBW7_1	0.0833
p.L1839R	DAN-G	pancreas	COSMIC	LTPTPDSS	DEG_SCF_FBW7_1	0.0833
p.N1844Y	SIDM01133	Other Solid Cancers	GDSC	LTPTPDSS	DEG_SCF_FBW7_1	0.2222
p.N1844Y	ACH-002177	Lung Cancer	CCLE	LTPTPDSS	DEG_SCF_FBW7_1	0.2222
p.N1844Y	NCI-H835	lung	COSMIC	LTPTPDSS	DEG_SCF_FBW7_1	0.2222
p.E1852G	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPTPDSS	DEG_SCF_FBW7_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_SCF_FBW7_1	1848:1855	LTPTPDSS	FBXW7	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons