DegronMD

Uniprot ID: O60673

Source protein: DNA polymerase zeta catalytic subunit

Source gene: REV3L

Class: DEG_APCC_KENBOX_2

Location: 641:645

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8481

ASA_SCORE: 104.12

COIL: 0.7496

CONS_SCORE: 0.2651

DSS_SCORE: 0.5137

HELIX: 0.2132

FCONS_SCORE: 1.1352

RIG_SCORE: 0.6425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H641N	TCGA-25-2398	OV	TCGA	HKENS	DEG_APCC_KENBOX_2	0.6312
p.H641N	DO31250	OV	ICGC	HKENS	DEG_APCC_KENBOX_2	0.6312
p.V652I	TCGA-D3-A5GS	SKCM	TCGA	HKENS	DEG_APCC_KENBOX_2	0.1389
p.V652I	DO47706	SKCM	ICGC	HKENS	DEG_APCC_KENBOX_2	0.1389
p.S640Y	TCGA-EO-A22R	UCEC	TCGA	HKENS	DEG_APCC_KENBOX_2	0.3056
p.S640Y	DO42713	UCEC	ICGC	HKENS	DEG_APCC_KENBOX_2	0.3056
p.P651S	TCGA-F4-6703	COAD	TCGA	HKENS	DEG_APCC_KENBOX_2	0.1667
p.P651S	DO9908	COAD	ICGC	HKENS	DEG_APCC_KENBOX_2	0.1667
p.V635I	DO222492	COCA	ICGC	HKENS	DEG_APCC_KENBOX_2	0.1667
p.E638K	DO234419	ESAD	ICGC	HKENS	DEG_APCC_KENBOX_2	0.25
p.H641Q	SIDM01261	Breast Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	0.647
p.H641Q	SIDM00730	Small Cell Lung Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	0.647
p.S633G	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	0.1111
p.S633G	SIDM00493	Other Solid Cancers	GDSC	HKENS	DEG_APCC_KENBOX_2	0.1111
p.S633G	SIDM01591	Breast Carcinoma	GDSC	HKENS	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60673	DNA polymerase zeta catalytic subunit	DEG_APCC_KENBOX_2	641:645	HKENS	APC,CDC20,FZR1	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons