DegronMD

Uniprot ID: Q9HC35

Source protein: Echinoderm microtubule-associated protein-like 4

Source gene: EML4

Class: DEG_SCF_SKP2-CKS1_1

Location: 486:493

E3 ligase: SKP2,CSK1

DEGRON score: 0.5145

ASA_SCORE: 69.8

COIL: 0.7575

CONS_SCORE: 0.5187

DSS_SCORE: 0.4222

HELIX: 0.05

FCONS_SCORE: 0.8731

RIG_SCORE: 0.7241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P489S	TCGA-BR-6452	STAD	TCGA	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.5641
p.S483I	TCGA-XM-A8RH	THYM	TCGA	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.25
p.G495D	DO223732	CESC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.L477M	DO8730	COAD	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L477M	DO43202	UCEC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L477M	DO41133	UCEC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A499V	DO50354	ESAD	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.6111
p.W478L	DO37782	SKCM	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.V500A	DO42568	UCEC	ICGC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S502N	SIDM00282	Colorectal Carcinoma	GDSC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.5278
p.S502N	ACH-000998	Colon/Colorectal Cancer	CCLE	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.5278
p.S502N	CW-2	large_intestine	COSMIC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.5278
p.M479I	SIDM01594	Breast Carcinoma	GDSC	TVEPTPGK	DEG_SCF_SKP2-CKS1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_SCF_SKP2-CKS1_1	486:493	TVEPTPGK	SKP2,CSK1	0.5145	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons