DegronMD

Uniprot ID: Q9HC35

Source protein: Echinoderm microtubule-associated protein-like 4

Source gene: EML4

Class: DEG_APCC_DBOX_1

Location: 191:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.943

ASA_SCORE: 93.8778

COIL: 0.8148

CONS_SCORE: 0.5111

DSS_SCORE: 0.5902

HELIX: 0.1403

FCONS_SCORE: 0.9681

RIG_SCORE: 0.6467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R192H	TCGA-09-0365	OV	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.8244
p.S184Y	TCGA-19-5956	GBM	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.5833
p.H182R	TCGA-42-2582	OV	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.0833
p.P199H	TCGA-AM-5821	COAD	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.6583
p.K207Q	TCGA-BS-A0UV	UCEC	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.2222
p.R192C	TCGA-CD-A4MI	STAD	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.8301
p.D189E	TCGA-CG-4301	STAD	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.2778
p.P206Q	TCGA-CV-7421	HNSC	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.1389
p.H182Y	TCGA-EY-A1GU	UCEC	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.0833
p.V208F	TCGA-F5-6814	READ	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.0833
p.W185C	TCGA-HE-7129	KIRP	TCGA	SRNKLSKIP	DEG_APCC_DBOX_1	0.1667
p.P183L	DO222420	MELA	ICGC	SRNKLSKIP	DEG_APCC_DBOX_1	0.1111
p.N188S	DO38599	STAD	ICGC	SRNKLSKIP	DEG_APCC_DBOX_1	0.25
p.R193I	DO41331	UCEC	ICGC	SRNKLSKIP	DEG_APCC_DBOX_1	0.8102
p.D190G	SIDM00224	Mesothelioma	GDSC	SRNKLSKIP	DEG_APCC_DBOX_1	0.3056
p.D190G	ACH-000569	Lung Cancer	CCLE	SRNKLSKIP	DEG_APCC_DBOX_1	0.3056
p.D190G	IST-MES1	pleura	COSMIC	SRNKLSKIP	DEG_APCC_DBOX_1	0.3056
p.I198V	ACH-001375	Pancreatic Cancer	CCLE	SRNKLSKIP	DEG_APCC_DBOX_1	0.5965
p.D187H	DJM-1	skin	COSMIC	SRNKLSKIP	DEG_APCC_DBOX_1	0.2222
p.D185N	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	SRNKLSKIP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC35	Echinoderm microtubule-associated protein-like 4	DEG_APCC_DBOX_1	191:199	SRNKLSKIP	APC,CDC20,FZR1	0.943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons