DegronMD

Uniprot ID: O95425

Source protein: Supervillin

Source gene: SVIL

Class: DEG_SCF_FBW7_2

Location: 1109:1115

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 81.2143

COIL: 0.7691

CONS_SCORE: 0.4424

DSS_SCORE: 0.4948

HELIX: 0.053

FCONS_SCORE: 1.064

RIG_SCORE: 0.6944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1112L	TCGA-2W-A8YY	CESC	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.7582
p.P1112L	TCGA-CA-5256	COAD	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.7582
p.P1112L	DO223732	CESC	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.7582
p.P1112L	DO10526	COAD	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.7582
p.T1111M	TCGA-34-2600	LUSC	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.8534
p.T1111M	TCGA-A5-A0G1	UCEC	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.8534
p.T1111M	DO27081	LUSC	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.8534
p.T1111M	DO42472	UCEC	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.8534
p.P1121A	TCGA-BQ-7046	KIRP	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.1667
p.P1121A	DO20885	KIRP	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.1667
p.S1120L	TCGA-DK-A1AC	BLCA	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.6389
p.S1120L	DO514	BLCA	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.6389
p.L1118P	TCGA-DU-6392	LGG	TCGA	IKTPTGE	DEG_SCF_FBW7_2	0.25
p.L1118P	DO22237	LGG	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.25
p.G1107V	DO223083	ESCA	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.2778
p.S1122R	DO229028	LICA	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.5833
p.M1125I	DO52677	MALY	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.0556
p.E1115D	DO38404	STAD	ICGC	IKTPTGE	DEG_SCF_FBW7_2	0.6758
p.M1103L	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKTPTGE	DEG_SCF_FBW7_2	0.1667
p.M1103L	ACH-000365	Lymphoma	CCLE	IKTPTGE	DEG_SCF_FBW7_2	0.1667
p.M1103L	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	IKTPTGE	DEG_SCF_FBW7_2	0.1667
p.R1111K	SNU-81	large_intestine	COSMIC	IKTPTGE	DEG_SCF_FBW7_2	0.7237
p.Q1118P	CAL-148	breast	COSMIC	IKTPTGE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95425	Supervillin	DEG_SCF_FBW7_2	1109:1115	IKTPTGE	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons