DegronMD

Uniprot ID: Q9Y2R2

Source protein: Tyrosine-protein phosphatase non-receptor type 22

Source gene: PTPN22

Class: DEG_SCF_FBW7_1

Location: 739:745

E3 ligase: FBXW7

DEGRON score: 0.8617

ASA_SCORE: 94.5286

COIL: 0.881

CONS_SCORE: 0.3705

DSS_SCORE: 0.5848

HELIX: 0.0509

FCONS_SCORE: 1.0642

RIG_SCORE: 0.6889

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R744M	DO38272	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.8632
p.T741I	SIDM01588	Endometrial Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.8189
p.T741I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LKTPGKS	DEG_SCF_FBW7_1	0.8189
p.P742L	TCGA-D3-A8GR	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.P742L	TCGA-ER-A19N	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.P742L	DO37452	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.P742L	DO51247	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.S745C	TCGA-EY-A1G8	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.7541
p.S745C	DO43578	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7541
p.P740A	DO228008	LAML	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7503
p.R744S	DO38272	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7427
p.G742E	DO229453	SKCA	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7199
p.S751N	SIDM00477	Esophageal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.6111
p.S751N	SIDM01003	T-Lymphoblastic Leukemia	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.6111
p.G743E	TCGA-GN-A266	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.G743E	TCGA-RP-A693	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.G743E	DO37432	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.G743E	DO51268	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.K744Q	TCGA-B5-A11E	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.5833
p.K744Q	DO41644	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.5833
p.K750N	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM01649	Non-Cancerous	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM01218	Other Solid Cancers	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM00118	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM00184	Melanoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056

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Drug responses associated with PTPN22 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LKTPGKS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SCF_FBW7_1	739:745	LKTPGKS	FBXW7	0.8617	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKTPGKS

Degron related mutations and impact score

Drug responses associated with PTPN22 mutations

All proteins holding degron of LKTPGKS