DegronMD

Uniprot ID: Q9Y2R2

Source protein: Tyrosine-protein phosphatase non-receptor type 22

Source gene: PTPN22

Class: DEG_SCF_FBW7_1

Location: 739:745

E3 ligase: FBXW7

DEGRON score: 0.8617

ASA_SCORE: 94.5286

COIL: 0.881

CONS_SCORE: 0.3705

DSS_SCORE: 0.5848

HELIX: 0.0509

FCONS_SCORE: 1.0642

RIG_SCORE: 0.6889

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S749C	TCGA-AJ-A3EK	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.2222
p.S749C	DO41584	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.2222
p.K744Q	TCGA-B5-A11E	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.5833
p.K744Q	DO41644	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.5833
p.P742L	TCGA-D3-A8GR	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.P742L	TCGA-ER-A19N	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.P742L	DO37452	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.P742L	DO51247	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7582
p.S732L	TCGA-EE-A2MR	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.1389
p.S732L	DO37819	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.1389
p.S745C	TCGA-EY-A1G8	UCEC	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.7541
p.S745C	DO43578	UCEC	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7541
p.G743E	TCGA-GN-A266	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.G743E	TCGA-RP-A693	SKCM	TCGA	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.G743E	DO37432	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.G743E	DO51268	SKCM	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.6087
p.P740A	DO228008	LAML	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7503
p.G742E	DO229453	SKCA	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7199
p.P748S	DO47973	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.25
p.R744S	DO38272	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.7427
p.R744M	DO38272	STAD	ICGC	LKTPGKS	DEG_SCF_FBW7_1	0.8632
p.K750N	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM01649	Non-Cancerous	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM01218	Other Solid Cancers	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM00118	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM00184	Melanoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.K750N	SIDM01613	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.3056
p.R748G	SIDM01023	Acute Myeloid Leukemia	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.25
p.R748G	SIDM01168	Colorectal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.25
p.S751N	SIDM00477	Esophageal Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.6111
p.S751N	SIDM01003	T-Lymphoblastic Leukemia	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.6111
p.T741I	SIDM01588	Endometrial Carcinoma	GDSC	LKTPGKS	DEG_SCF_FBW7_1	0.8189
p.T741I	ACH-000993	Endometrial/Uterine Cancer	CCLE	LKTPGKS	DEG_SCF_FBW7_1	0.8189

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKTPGKS

Degron related mutations and impact score

Drug responses associated with PTPN22 mutations

All proteins holding degron of LKTPGKS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2R2	Tyrosine-protein phosphatase non-receptor type 22	DEG_SCF_FBW7_1	739:745	LKTPGKS	FBXW7	0.8617	More...