DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: LIG_APCC_ABBA_1

Location: 502:507

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9603

ASA_SCORE: 84.3333

COIL: 0.6185

CONS_SCORE: 0.3945

DSS_SCORE: 0.5584

HELIX: 0.3338

FCONS_SCORE: 1.198

RIG_SCORE: 0.7352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A492V	TCGA-AB-2828	LAML	TCGA	LNLFED	LIG_APCC_ABBA_1	0.0556
p.Q509L	SIDM01119	Other Solid Cancers	GDSC	LNLFED	LIG_APCC_ABBA_1	0.2778
p.Q509L	ACH-000775	Lung Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	0.2778
p.Q509L	NCI-H727	lung	COSMIC	LNLFED	LIG_APCC_ABBA_1	0.2778
p.P517R	SIDM00930	Osteosarcoma	GDSC	LNLFED	LIG_APCC_ABBA_1	0.0556
p.P517R	ACH-001715	Bone Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	0.0556
p.P517R	CAL-72	bone	COSMIC	LNLFED	LIG_APCC_ABBA_1	0.0556
p.A492T	SIDM00217	Colorectal Carcinoma	GDSC	LNLFED	LIG_APCC_ABBA_1	0.0556
p.A492T	ACH-000999	Colon/Colorectal Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	0.0556
p.A492T	SNU-1040	large_intestine	COSMIC	LNLFED	LIG_APCC_ABBA_1	0.0556
p.E514A	ACH-000389	Brain Cancer	CCLE	LNLFED	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WKZ4	Rab11 family-interacting protein 1	LIG_APCC_ABBA_1	502:507	LNLFED	APC,CDC20,FZR1	0.9603	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons