DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: DEG_COP1_1

Location: 1089:1098

E3 ligase: COP1

DEGRON score: 0.9692

ASA_SCORE: 93.57

COIL: 0.9603

CONS_SCORE: 0.3961

DSS_SCORE: 0.794

HELIX: 0.0219

FCONS_SCORE: 1.3303

RIG_SCORE: 0.5291

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1092V	TCGA-CN-4741	HNSC	TCGA	TSLDNPVPSP	DEG_COP1_1	0.7785
p.D1092V	DO14313	HNSC	ICGC	TSLDNPVPSP	DEG_COP1_1	0.7785
p.D1092H	SIDM00040	Gastric Carcinoma	GDSC	TSLDNPVPSP	DEG_COP1_1	0.7688
p.D1092H	SIDM00171	Colorectal Carcinoma	GDSC	TSLDNPVPSP	DEG_COP1_1	0.7688
p.D1092H	TMK-1	stomach	COSMIC	TSLDNPVPSP	DEG_COP1_1	0.7688
p.P1096T	DO229025	LICA	ICGC	TSLDNPVPSP	DEG_COP1_1	0.7031
p.L1091P	SIDM00422	Hodgkin's Lymphoma	GDSC	TSLDNPVPSP	DEG_COP1_1	0.6471
p.L1091P	ACH-001203	Lymphoma	CCLE	TSLDNPVPSP	DEG_COP1_1	0.6471
p.L1091P	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	TSLDNPVPSP	DEG_COP1_1	0.6471
p.D1092E	DO229045	LICA	ICGC	TSLDNPVPSP	DEG_COP1_1	0.5647
p.S1099F	TCGA-AA-3663	COAD	TCGA	TSLDNPVPSP	DEG_COP1_1	0.3056
p.S1099F	DO9346	COAD	ICGC	TSLDNPVPSP	DEG_COP1_1	0.3056
p.P1087A	TCGA-IZ-A6M8	KIRP	TCGA	TSLDNPVPSP	DEG_COP1_1	0.2778
p.P1087A	DO48489	KIRP	ICGC	TSLDNPVPSP	DEG_COP1_1	0.2778
p.P1085L	SIDM02050	Colorectal Carcinoma	GDSC	TSLDNPVPSP	DEG_COP1_1	0.2222
p.S1084R	DO224855	BRCA	ICGC	TSLDNPVPSP	DEG_COP1_1	0.1944
p.P1083S	TCGA-B5-A3FC	UCEC	TCGA	TSLDNPVPSP	DEG_COP1_1	0.1667
p.P1083S	DO41871	UCEC	ICGC	TSLDNPVPSP	DEG_COP1_1	0.1667
p.P1083Q	TCGA-DU-5854	LGG	TCGA	TSLDNPVPSP	DEG_COP1_1	0.1667
p.P1083Q	DO22466	LGG	ICGC	TSLDNPVPSP	DEG_COP1_1	0.1667
p.P1083L	SIDM01113	Other Sarcomas	GDSC	TSLDNPVPSP	DEG_COP1_1	0.1667
p.S1082N	TCGA-DF-A2KU	UCEC	TCGA	TSLDNPVPSP	DEG_COP1_1	0.1389
p.S1082N	DO223286	UCEC	ICGC	TSLDNPVPSP	DEG_COP1_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WKZ4	Rab11 family-interacting protein 1	DEG_COP1_1	1089:1098	TSLDNPVPSP	COP1	0.9692	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons