DegronMD

Uniprot ID: Q6WKZ4

Source protein: Rab11 family-interacting protein 1

Source gene: RAB11FIP1

Class: DEG_SCF_TRCP1_1

Location: 183:188

E3 ligase: BTRC

DEGRON score: 0.996

ASA_SCORE: 77.6333

COIL: 0.8468

CONS_SCORE: 0.4734

DSS_SCORE: 0.5545

HELIX: 0.1182

FCONS_SCORE: 0.871

RIG_SCORE: 0.6112

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S190T	TCGA-24-2280	OV	TCGA	DSGSDT	DEG_SCF_TRCP1_1	0.7222
p.K184N	DO22237	LGG	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.6918
p.P196Q	DO228985	LICA	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.1111
p.Y177C	DO26434	LUSC	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.1667
p.G173V	DO229068	PRAD	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.0556
p.S194Y	DO218857	SKCA	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.1667
p.P198L	DO37487	SKCM	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.0556
p.S197F	DO38045	SKCM	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.0833
p.A183V	DO41644	UCEC	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.6936
p.G185C	DO42873	UCEC	ICGC	DSGSDT	DEG_SCF_TRCP1_1	0.76
p.S195R	SIDM00458	Acute Myeloid Leukemia	GDSC	DSGSDT	DEG_SCF_TRCP1_1	0.1389
p.S195R	ACH-000751	Leukemia	CCLE	DSGSDT	DEG_SCF_TRCP1_1	0.1389
p.S195R	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSDT	DEG_SCF_TRCP1_1	0.1389
p.L178V	OCI-AML3	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSDT	DEG_SCF_TRCP1_1	0.3056
p.P192L	CAL-12T	lung	COSMIC	DSGSDT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SCF_TRCP1_1	183:188	DSGSDT	BTRC	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons