DegronMD

Uniprot ID: O60741

Source protein: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Source gene: HCN1

Class: DEG_SCF_FBW7_1

Location: 755:761

E3 ligase: FBXW7

DEGRON score: 0.968

ASA_SCORE: 84.5571

COIL: 0.9619

CONS_SCORE: 0.2251

DSS_SCORE: 0.9353

HELIX: 0.017

FCONS_SCORE: 0.8778

RIG_SCORE: 0.4259

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P748L	TCGA-17-Z062	LUAD	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.1389
p.P748L	DO23543	LIRI	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.1389
p.T771K	TCGA-55-8203	LUAD	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771K	DO218928	LUAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.S770G	TCGA-66-2791	LUSC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.5278
p.S770G	DO231127	LUSC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5278
p.S770G	DO26435	LUSC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5278
p.N765H	TCGA-A6-2674	COAD	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.2222
p.N765H	DO7819	COAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2222
p.E766K	TCGA-DD-AAE3	LIHC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	TCGA-EB-A3XC	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	TCGA-GF-A4EO	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	TCGA-KQ-A41S	BLCA	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	DO223593	BLCA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	DO52258	LIHC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	DO37579	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.E766K	DO47559	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.1944
p.T771M	TCGA-DF-A2KU	UCEC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	TCGA-EY-A215	UCEC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	TCGA-L5-A891	ESCA	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	TCGA-NK-A5CX	LUSC	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	DO233829	GACA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	DO219211	LUSC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	DO223286	UCEC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.T771M	DO42665	UCEC	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.P763Q	TCGA-EB-A299	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763Q	DO37794	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763S	TCGA-FR-A8YC	SKCM	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763S	DO50301	SKCM	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763L	TCGA-OL-A6VQ	BRCA	TCGA	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763L	DO51214	BRCA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763L	DO228838	MALY	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.P763L	DO50421	PRAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2778
p.K769N	DO1073	BRCA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.2222
p.T771A	DO234340	ESAD	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.5
p.V767A	DO233804	GACA	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.1667
p.Q756H	DO45163	LIRI	ICGC	PQTPGSS	DEG_SCF_FBW7_1	0.647
p.S760I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PQTPGSS	DEG_SCF_FBW7_1	0.623
p.S760I	ACH-000636	Leukemia	CCLE	PQTPGSS	DEG_SCF_FBW7_1	0.623
p.S760I	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPGSS	DEG_SCF_FBW7_1	0.623
p.Q756K	SIDM00120	Prostate Carcinoma	GDSC	PQTPGSS	DEG_SCF_FBW7_1	0.5833
p.Q756K	ACH-000979	Prostate Cancer	CCLE	PQTPGSS	DEG_SCF_FBW7_1	0.5833
p.Q756K	DU-145	prostate	COSMIC	PQTPGSS	DEG_SCF_FBW7_1	0.5833
p.T771S	ACH-001664	Gastric Cancer	CCLE	PQTPGSS	DEG_SCF_FBW7_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTPGSS

Degron related mutations and impact score

Drug responses associated with HCN1 mutations

All proteins holding degron of PQTPGSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SCF_FBW7_1	755:761	PQTPGSS	FBXW7	0.968	More...