DegronMD

Uniprot ID: Q6K0P9

Source protein: Pyrin and HIN domain-containing protein 1

Source gene: PYHIN1

Class: DEG_SPOP_SBC_1

Location: 167:171

E3 ligase: SPOP

DEGRON score: 0.8521

ASA_SCORE: 73.16

COIL: 0.8568

CONS_SCORE: 0.5732

DSS_SCORE: 0.7784

HELIX: 0.0948

FCONS_SCORE: 0.8144

RIG_SCORE: 0.5575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G166V	TCGA-49-AARO	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	0.3056
p.G166V	DO218924	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.3056
p.R175H	TCGA-66-2792	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	0.2222
p.R175H	DO26451	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R175H	DO50416	PRAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R175H	ACH-001857	Bile Duct Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.2222
p.A167D	TCGA-80-5611	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	0.7793
p.A167D	DO23822	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.7793
p.T171A	TCGA-91-6829	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	0.7139
p.T171A	DO23564	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.7139
p.E157V	TCGA-A5-A0G2	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.0556
p.E157V	DO41235	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	0.0556
p.P161S	TCGA-B5-A3FC	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.1667
p.P161S	TCGA-FZ-5921	PAAD	TCGA	ASTST	DEG_SPOP_SBC_1	0.1667
p.P161S	DO51688	PAAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.1667
p.P161S	DO41871	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	0.1667
p.S162F	TCGA-EE-A29S	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.1944
p.S162F	DO37936	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.1944
p.A172V	DO234437	ESAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.3056
p.R175C	DO233757	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	0.2222
p.A167S	DO233746	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	0.7588
p.P178R	SIDM00159	Biliary Tract Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.1389
p.P170L	COLO-792	skin	COSMIC	ASTST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNY8	Ubiquitin carboxyl-terminal hydrolase 27	DEG_SPOP_SBC_1	27:31	ASTST	SPOP	0.9855	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	734:738	ASTST	SPOP	0.8404	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	99:103	ASTST	SPOP	0.8869	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	97:101	ASTST	SPOP	0.6734	More...
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	DEG_SPOP_SBC_1	1169:1173	ASTST	SPOP	0.9333	More...
P02538	Keratin, type II cytoskeletal 6A	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.999	More...
P04259	Keratin, type II cytoskeletal 6B	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9988	More...
P48668	Keratin, type II cytoskeletal 6C	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9972	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	167:171	ASTST	SPOP	0.8521	More...
Q86XK2	F-box only protein 11	DEG_SPOP_SBC_1	122:126	ASTST	SPOP	0.9941	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	155:159	ASTST	SPOP	0.9985	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	327:331	ASTST	SPOP	0.9874	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1037:1041	ASTST	SPOP	0.9933	More...
Q9HCI7	E3 ubiquitin-protein ligase MSL2	DEG_SPOP_SBC_1	539:543	ASTST	SPOP	0.6886	More...
Q9UBY0	Sodium/hydrogen exchanger 2	DEG_SPOP_SBC_1	660:664	ASTST	SPOP	0.9628	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1446:1450	ASTST	SPOP	0.9987	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	551:555	ASTST	SPOP	0.8329	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2152:2156	ASTST	SPOP	0.9897	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	177:181	ASTST	SPOP	0.9989	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9534	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9582	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9382	More...
Q15884	Protein FAM189A2	DEG_SPOP_SBC_1	247:251	ASTST	SPOP	0.9933	More...
Q96QE4	Leucine-rich repeat-containing protein 37B	DEG_SPOP_SBC_1	514:518	ASTST	SPOP	0.9492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTST

Degron related mutations and impact score

Drug responses associated with PYHIN1 mutations

All proteins holding degron of ASTST