DegronMD

Uniprot ID: P48668

Source protein: Keratin, type II cytoskeletal 6C

Source gene: KRT6C

Class: DEG_SPOP_SBC_1

Location: 2:6

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 70.86

COIL: 0.7354

CONS_SCORE: 0.4723

DSS_SCORE: 0.8892

HELIX: 0.0092

FCONS_SCORE: 1.0953

RIG_SCORE: 0.6736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S13N	TCGA-A8-A07G	BRCA	TCGA	ASTST	DEG_SPOP_SBC_1	0.1389
p.S13N	DO2870	BRCA	ICGC	ASTST	DEG_SPOP_SBC_1	0.1389
p.T4A	TCGA-AP-A0LM	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.7139
p.T4A	DO43306	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	0.7139
p.R16W	TCGA-DF-A2KU	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.0556
p.R16W	DO223286	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	0.0556
p.S12N	TCGA-DU-6392	LGG	TCGA	ASTST	DEG_SPOP_SBC_1	0.1667
p.S12N	DO22237	LGG	ICGC	ASTST	DEG_SPOP_SBC_1	0.1667
p.R15H	TCGA-DX-A3M2	SARC	TCGA	ASTST	DEG_SPOP_SBC_1	0.0833
p.R15H	DO219971	SARC	ICGC	ASTST	DEG_SPOP_SBC_1	0.0833
p.S5F	TCGA-EE-A3AG	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.9093
p.S5F	DO37471	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.9093
p.S14R	DO228815	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	0.1111
p.S13C	DO231191	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	0.1389
p.R16Q	DO46378	OV	ICGC	ASTST	DEG_SPOP_SBC_1	0.0556
p.S5C	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.8652
p.S5C	ACH-000727	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.8652
p.S5C	NCI-H2066	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	0.8652
p.R15C	SIDM01368	Gastric Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNY8	Ubiquitin carboxyl-terminal hydrolase 27	DEG_SPOP_SBC_1	27:31	ASTST	SPOP	0.9855	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	734:738	ASTST	SPOP	0.8404	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	99:103	ASTST	SPOP	0.8869	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	97:101	ASTST	SPOP	0.6734	More...
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	DEG_SPOP_SBC_1	1169:1173	ASTST	SPOP	0.9333	More...
P02538	Keratin, type II cytoskeletal 6A	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.999	More...
P04259	Keratin, type II cytoskeletal 6B	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9988	More...
P48668	Keratin, type II cytoskeletal 6C	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9972	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	167:171	ASTST	SPOP	0.8521	More...
Q86XK2	F-box only protein 11	DEG_SPOP_SBC_1	122:126	ASTST	SPOP	0.9941	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	155:159	ASTST	SPOP	0.9985	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	327:331	ASTST	SPOP	0.9874	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1037:1041	ASTST	SPOP	0.9933	More...
Q9HCI7	E3 ubiquitin-protein ligase MSL2	DEG_SPOP_SBC_1	539:543	ASTST	SPOP	0.6886	More...
Q9UBY0	Sodium/hydrogen exchanger 2	DEG_SPOP_SBC_1	660:664	ASTST	SPOP	0.9628	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1446:1450	ASTST	SPOP	0.9987	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	551:555	ASTST	SPOP	0.8329	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2152:2156	ASTST	SPOP	0.9897	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	177:181	ASTST	SPOP	0.9989	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9534	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9582	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9382	More...
Q15884	Protein FAM189A2	DEG_SPOP_SBC_1	247:251	ASTST	SPOP	0.9933	More...
Q96QE4	Leucine-rich repeat-containing protein 37B	DEG_SPOP_SBC_1	514:518	ASTST	SPOP	0.9492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTST

Degron related mutations and impact score

Drug responses associated with KRT6C mutations

All proteins holding degron of ASTST