DegronMD - P48668(KRT6C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S13N	TCGA-A8-A07G	BRCA	TCGA	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.S13N	DO2870	BRCA	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.T4A	TCGA-AP-A0LM	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7139
p.T4A	DO43306	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.7139
p.R16W	TCGA-DF-A2KU	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.R16W	DO223286	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.S12N	TCGA-DU-6392	LGG	TCGA	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.S12N	DO22237	LGG	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.R15H	TCGA-DX-A3M2	SARC	TCGA	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.R15H	DO219971	SARC	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.S5F	TCGA-EE-A3AG	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.9093
p.S5F	DO37471	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.9093
p.S14R	DO228815	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1111
p.S13C	DO231191	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.R16Q	DO46378	OV	ICGC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0556
p.S5C	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8652
p.S5C	ACH-000727	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8652
p.S5C	NCI-H2066	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.8652
p.R15C	SIDM01368	Gastric Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833

Kaplan plot for KRT6C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT6C

UniProt ID: P48668

Entrez ID: 286887

Protein name: Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT6C in