DegronMD - Q96QE4(LRRC37B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T459S	TCGA-77-7337	LUSC	TCGA	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.3056
p.T459S	DO27445	LUSC	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.3056
p.I520T	TCGA-A5-A0G1	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.I520T	DO42472	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.Q512H	TCGA-BR-6452	STAD	TCGA	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.Q512H	DO38404	STAD	ICGC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.I520R	TCGA-CN-6989	HNSC	TCGA	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.I520R	DO14814	HNSC	ICGC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2778
p.A466V	TCGA-D7-A6EY	STAD	TCGA	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1111
p.A466V	DO50118	STAD	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1111
p.L451F	TCGA-D8-A1X9	BRCA	TCGA	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.6981
p.E511K	DO51599	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.25
p.R461H	DO219915	DLBC	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.25
p.Q445H	DO228952	LICA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1667
p.T448N	DO228974	LICA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.25
p.I453T	DO220883	MELA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.5966
p.T465K	DO232018	ORCA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1389
p.E460D	SIDM01267	Non-Cancerous	GDSC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.2778
p.T516I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7078
p.T516I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7078
p.G527R	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833
p.G527R	ACH-000309	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833
p.G527R	SK-LU-1	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833
p.E522D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.E522D	ACH-000851	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.T528I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.E468K	Farage	haematopoietic and lymphoid tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.0556
p.S524Y	HT-115	large intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.E441K	Farage	haematopoietic and lymphoid tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.0556
p.L446V	NCI-H2342	lung	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1944
p.F517S	HCC1569	breast	COSMIC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7982
p.G445R	SK-LU-1	lung	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1667
p.E452D	Farage	haematopoietic and lymphoid tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.6758
p.E467D	Farage	haematopoietic and lymphoid tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.0833
p.P464L	NCI-H1734	lung	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation rewiring degron network	0.1667
p.E453K	Farage	haematopoietic and lymphoid tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	451:458	Mutation altering degron motif	0.7022
p.S509Y	HT-115	large intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC37B

UniProt ID: Q96QE4

Entrez ID: 114659

Protein name: Leucine-rich repeat-containing protein 37B (C66 SLIT-like testicular protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC37B in