DegronMD

Uniprot ID: Q96QE4

Source protein: Leucine-rich repeat-containing protein 37B

Source gene: LRRC37B

Class: DEG_SPOP_SBC_1

Location: 514:518

E3 ligase: SPOP

DEGRON score: 0.9492

ASA_SCORE: 74.14

COIL: 0.8242

CONS_SCORE: 0.6011

DSS_SCORE: 0.2999

HELIX: 0.1068

FCONS_SCORE: 1.1337

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I520T	TCGA-A5-A0G1	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.2778
p.I520T	DO42472	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	0.2778
p.Q512H	TCGA-BR-6452	STAD	TCGA	ASTST	DEG_SPOP_SBC_1	0.2778
p.Q512H	DO38404	STAD	ICGC	ASTST	DEG_SPOP_SBC_1	0.2778
p.I520R	TCGA-CN-6989	HNSC	TCGA	ASTST	DEG_SPOP_SBC_1	0.2778
p.I520R	DO14814	HNSC	ICGC	ASTST	DEG_SPOP_SBC_1	0.2778
p.E511K	DO51599	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	0.25
p.T516I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ASTST	DEG_SPOP_SBC_1	0.7078
p.T516I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	0.7078
p.G527R	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.0833
p.G527R	ACH-000309	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.0833
p.G527R	SK-LU-1	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	0.0833
p.E522D	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.E522D	ACH-000851	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.2222
p.T528I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	0.0556
p.S524Y	HT-115	large_intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	0.1667
p.F517S	HCC1569	breast	COSMIC	ASTST	DEG_SPOP_SBC_1	0.7982
p.S509Y	HT-115	large_intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNY8	Ubiquitin carboxyl-terminal hydrolase 27	DEG_SPOP_SBC_1	27:31	ASTST	SPOP	0.9855	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	734:738	ASTST	SPOP	0.8404	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	99:103	ASTST	SPOP	0.8869	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	97:101	ASTST	SPOP	0.6734	More...
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	DEG_SPOP_SBC_1	1169:1173	ASTST	SPOP	0.9333	More...
P02538	Keratin, type II cytoskeletal 6A	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.999	More...
P04259	Keratin, type II cytoskeletal 6B	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9988	More...
P48668	Keratin, type II cytoskeletal 6C	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9972	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	167:171	ASTST	SPOP	0.8521	More...
Q86XK2	F-box only protein 11	DEG_SPOP_SBC_1	122:126	ASTST	SPOP	0.9941	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	155:159	ASTST	SPOP	0.9985	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	327:331	ASTST	SPOP	0.9874	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1037:1041	ASTST	SPOP	0.9933	More...
Q9HCI7	E3 ubiquitin-protein ligase MSL2	DEG_SPOP_SBC_1	539:543	ASTST	SPOP	0.6886	More...
Q9UBY0	Sodium/hydrogen exchanger 2	DEG_SPOP_SBC_1	660:664	ASTST	SPOP	0.9628	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1446:1450	ASTST	SPOP	0.9987	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	551:555	ASTST	SPOP	0.8329	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2152:2156	ASTST	SPOP	0.9897	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	177:181	ASTST	SPOP	0.9989	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9534	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9582	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9382	More...
Q15884	Protein FAM189A2	DEG_SPOP_SBC_1	247:251	ASTST	SPOP	0.9933	More...
Q96QE4	Leucine-rich repeat-containing protein 37B	DEG_SPOP_SBC_1	514:518	ASTST	SPOP	0.9492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTST

Degron related mutations and impact score

Drug responses associated with LRRC37B mutations

All proteins holding degron of ASTST