DegronMD

Uniprot ID: Q9HCI7

Source protein: E3 ubiquitin-protein ligase MSL2

Source gene: MSL2

Class: DEG_SPOP_SBC_1

Location: 539:543

E3 ligase: SPOP

DEGRON score: 0.6886

ASA_SCORE: 78.14

COIL: 0.8894

CONS_SCORE: 0.4363

DSS_SCORE: 0.2303

HELIX: 0.0464

FCONS_SCORE: 0.9432

RIG_SCORE: 0.7393

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S544R	TCGA-12-0692	GBM	TCGA	ASTST	DEG_SPOP_SBC_1	0.3056
p.S544R	TCGA-D1-A17Q	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.3056
p.S544I	TCGA-37-3789	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	0.3056
p.N538K	TCGA-91-6828	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	0.3056
p.V531A	TCGA-A5-A1OF	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.1111
p.A535T	TCGA-AC-A23H	BRCA	TCGA	ASTST	DEG_SPOP_SBC_1	0.2222
p.I534V	TCGA-AP-A051	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.1944
p.S542G	TCGA-AX-A06F	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.6993
p.N530S	TCGA-D3-A8GM	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.0833
p.P552L	TCGA-D9-A4Z3	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.0833
p.P552S	TCGA-D9-A4Z3	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.0833
p.V536A	TCGA-FI-A2D5	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	0.25
p.S540N	SIDM00866	Breast Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00973	Melanoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM01169	Ovarian Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM01233	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00953	Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00419	Ewing's Sarcoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00790	Non-Cancerous	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00092	Ovarian Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM01118	Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00868	Non-Cancerous	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.S540N	SIDM00527	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7069
p.R537H	SIDM00965	Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2778
p.R537H	ACH-000800	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.2778
p.R537H	NCI-H446	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	0.2778
p.T543I	SIDM00272	Breast Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7078
p.T543I	ACH-000910	Breast Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.7078
p.T543I	MDA-MB-453	breast	COSMIC	ASTST	DEG_SPOP_SBC_1	0.7078
p.S542C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7541
p.S542C	ACH-002101	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.7541
p.S542C	EMC-BAC-1	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	0.7541
p.V545L	SIDM00257	Neuroblastoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2778
p.V545L	ACH-002280	Neuroblastoma	CCLE	ASTST	DEG_SPOP_SBC_1	0.2778
p.V545L	NB13	autonomic_ganglia	COSMIC	ASTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNY8	Ubiquitin carboxyl-terminal hydrolase 27	DEG_SPOP_SBC_1	27:31	ASTST	SPOP	0.9855	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	734:738	ASTST	SPOP	0.8404	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	99:103	ASTST	SPOP	0.8869	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	97:101	ASTST	SPOP	0.6734	More...
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	DEG_SPOP_SBC_1	1169:1173	ASTST	SPOP	0.9333	More...
P02538	Keratin, type II cytoskeletal 6A	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.999	More...
P04259	Keratin, type II cytoskeletal 6B	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9988	More...
P48668	Keratin, type II cytoskeletal 6C	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9972	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	167:171	ASTST	SPOP	0.8521	More...
Q86XK2	F-box only protein 11	DEG_SPOP_SBC_1	122:126	ASTST	SPOP	0.9941	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	155:159	ASTST	SPOP	0.9985	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	327:331	ASTST	SPOP	0.9874	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1037:1041	ASTST	SPOP	0.9933	More...
Q9HCI7	E3 ubiquitin-protein ligase MSL2	DEG_SPOP_SBC_1	539:543	ASTST	SPOP	0.6886	More...
Q9UBY0	Sodium/hydrogen exchanger 2	DEG_SPOP_SBC_1	660:664	ASTST	SPOP	0.9628	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1446:1450	ASTST	SPOP	0.9987	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	551:555	ASTST	SPOP	0.8329	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2152:2156	ASTST	SPOP	0.9897	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	177:181	ASTST	SPOP	0.9989	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9534	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9582	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9382	More...
Q15884	Protein FAM189A2	DEG_SPOP_SBC_1	247:251	ASTST	SPOP	0.9933	More...
Q96QE4	Leucine-rich repeat-containing protein 37B	DEG_SPOP_SBC_1	514:518	ASTST	SPOP	0.9492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTST

Degron related mutations and impact score

Drug responses associated with MSL2 mutations

All proteins holding degron of ASTST