DegronMD

Uniprot ID: Q9UBY0

Source protein: Sodium/hydrogen exchanger 2

Source gene: SLC9A2

Class: DEG_SPOP_SBC_1

Location: 660:664

E3 ligase: SPOP

DEGRON score: 0.9628

ASA_SCORE: 85.74

COIL: 0.8764

CONS_SCORE: 0.3579

DSS_SCORE: 0.5774

HELIX: 0.1116

FCONS_SCORE: 0.9218

RIG_SCORE: 0.628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S665F	TCGA-18-3409	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	0.75
p.S665F	DO26444	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	0.75
p.N673S	TCGA-56-8503	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	0.0833
p.N673S	DO45444	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	0.0833
p.R666Q	TCGA-EB-A44O	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.2778
p.R666Q	TCGA-GF-A6C9	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.2778
p.R666Q	DO47272	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.2778
p.R666Q	DO51254	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.2778
p.R666Q	SIDM01588	Endometrial Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2778
p.S661F	TCGA-FR-A726	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.7982
p.S661F	TCGA-IR-A3LI	CESC	TCGA	ASTST	DEG_SPOP_SBC_1	0.7982
p.S661F	DO44400	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	0.7982
p.S661F	DO48665	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.7982
p.D651N	TCGA-FR-A7U9	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.0833
p.D651N	DO48546	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.0833
p.S669F	TCGA-W3-AA1W	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	0.6389
p.S669F	DO51277	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	0.6389
p.T674M	DO233272	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	0.5
p.R656L	DO229029	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	0.2222
p.K650N	DO229028	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	0.1667
p.T674A	DO23546	LIRI	ICGC	ASTST	DEG_SPOP_SBC_1	0.5
p.KD650KN	DO222843	MELA	ICGC	ASTST	DEG_SPOP_SBC_1	0.1111
p.R656Q	SIDM00088	Prostate Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R656Q	SIDM00908	Non-Cancerous	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R656Q	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R656Q	SIDM00265	Ewing's Sarcoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R656Q	SIDM00909	Melanoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.R656Q	SIDM00701	Non-Cancerous	GDSC	ASTST	DEG_SPOP_SBC_1	0.2222
p.S663L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	0.7667
p.S663L	ACH-000892	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	0.7667
p.S663L	NCI-H1563	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NNY8	Ubiquitin carboxyl-terminal hydrolase 27	DEG_SPOP_SBC_1	27:31	ASTST	SPOP	0.9855	More...
O14490	Disks large-associated protein 1	DEG_SPOP_SBC_1	734:738	ASTST	SPOP	0.8404	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	99:103	ASTST	SPOP	0.8869	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	97:101	ASTST	SPOP	0.6734	More...
O95153	Peripheral-type benzodiazepine receptor-associated protein 1	DEG_SPOP_SBC_1	1169:1173	ASTST	SPOP	0.9333	More...
P02538	Keratin, type II cytoskeletal 6A	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.999	More...
P04259	Keratin, type II cytoskeletal 6B	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9988	More...
P48668	Keratin, type II cytoskeletal 6C	DEG_SPOP_SBC_1	2:6	ASTST	SPOP	0.9972	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	167:171	ASTST	SPOP	0.8521	More...
Q86XK2	F-box only protein 11	DEG_SPOP_SBC_1	122:126	ASTST	SPOP	0.9941	More...
Q96FF9	Sororin	DEG_SPOP_SBC_1	155:159	ASTST	SPOP	0.9985	More...
Q99583	Max-binding protein MNT	DEG_SPOP_SBC_1	327:331	ASTST	SPOP	0.9874	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1037:1041	ASTST	SPOP	0.9933	More...
Q9HCI7	E3 ubiquitin-protein ligase MSL2	DEG_SPOP_SBC_1	539:543	ASTST	SPOP	0.6886	More...
Q9UBY0	Sodium/hydrogen exchanger 2	DEG_SPOP_SBC_1	660:664	ASTST	SPOP	0.9628	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1446:1450	ASTST	SPOP	0.9987	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	551:555	ASTST	SPOP	0.8329	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2152:2156	ASTST	SPOP	0.9897	More...
Q8IWB9	Testis-expressed protein 2	DEG_SPOP_SBC_1	177:181	ASTST	SPOP	0.9989	More...
A6NM11	Leucine-rich repeat-containing protein 37A2	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9534	More...
A6NMS7	Leucine-rich repeat-containing protein 37A	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9582	More...
O60309	Leucine-rich repeat-containing protein 37A3	DEG_SPOP_SBC_1	824:828	ASTST	SPOP	0.9382	More...
Q15884	Protein FAM189A2	DEG_SPOP_SBC_1	247:251	ASTST	SPOP	0.9933	More...
Q96QE4	Leucine-rich repeat-containing protein 37B	DEG_SPOP_SBC_1	514:518	ASTST	SPOP	0.9492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTST

Degron related mutations and impact score

Drug responses associated with SLC9A2 mutations

All proteins holding degron of ASTST