DegronMD - Q99583(MNT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A468T	TCGA-2W-A8YY	CESC	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.2778
p.A468T	TCGA-AA-3864	COAD	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.2778
p.A468T	DO223732	CESC	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.2778
p.A468T	DO8490	COAD	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.2778
p.P322L	TCGA-90-A4ED	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.P322L	TCGA-YG-AA3N	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.P322L	DO45482	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.P322L	DO51298	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.S330C	TCGA-AC-A5XS	BRCA	TCGA	ASTST	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7541
p.S330C	DO50023	BRCA	ICGC	ASTST	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7541
p.G489V	TCGA-BQ-7060	KIRP	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.1111
p.G489V	DO20831	KIRP	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.1111
p.G464D	TCGA-D1-A16F	UCEC	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.1667
p.G464D	DO42408	UCEC	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.1667
p.R317L	TCGA-D3-A2JO	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.R317L	DO47619	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.P361S	TCGA-EE-A29E	SKCM	TCGA	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0833
p.P361S	DO37831	SKCM	ICGC	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0833
p.A482V	TCGA-HU-A4GU	STAD	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.3056
p.A482V	DO47849	STAD	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.3056
p.P487H	TCGA-KR-A7K2	LIHC	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.1667
p.P487H	DO49697	LIHC	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.1667
p.A471T	DO50090	COAD	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation altering degron motif	0.7139
p.A471T	DO228935	COCA	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation altering degron motif	0.7139
p.A471T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation altering degron motif	0.7139
p.A376V	DO222765	COCA	ICGC	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.2778
p.P184T	DO228976	LICA	ICGC	PLPTPVLT	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.H469N	DO44808	LICA	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.3056
p.K365N	DO232761	PBCA	ICGC	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation substituting flanking lysine	0.3056
p.A177V	DO42673	UCEC	ICGC	PLPTPVLT	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.L166W	SIDM00258	Neuroblastoma	GDSC	PLPTPVLT	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.E341K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.E341K	ACH-002215	Lymphoma	CCLE	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.E341K	BC-3	haematopoietic and lymphoid tissue	COSMIC	ASTST	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.0556
p.A177T	SIDM00333	Endometrial Carcinoma	GDSC	PLPTPVLT	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.A177T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PLPTPVLT	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.A177T	MFE-319	endometrium	COSMIC	PLPTPVLT	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.P361L	SIDM00294	Small Cell Lung Carcinoma	GDSC	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0833
p.P361L	ACH-001549	Lung Cancer	CCLE	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0833
p.P361L	LU-135	lung	COSMIC	PPSTT	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.0833
p.A484V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation rewiring degron network	0.25
p.V479L	SIDM00996	Thyroid Gland Carcinoma	GDSC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation altering degron motif	0.5654
p.V479L	ACH-001307	Thyroid Cancer	CCLE	IAPSAPSPAVQL	DEG_ODPH_VHL_1	470:481	Mutation altering degron motif	0.5654

Kaplan plot for MNT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MNT

UniProt ID: Q99583

Entrez ID: 4335

Protein name: Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MNT in