DegronMD

Uniprot ID: Q99583

Source protein: Max-binding protein MNT

Source gene: MNT

Class: DEG_SCF_FBW7_1

Location: 168:175

E3 ligase: FBXW7

DEGRON score: 0.9803

ASA_SCORE: 79.6625

COIL: 0.8454

CONS_SCORE: 0.3775

DSS_SCORE: 0.6651

HELIX: 0.0181

FCONS_SCORE: 0.9191

RIG_SCORE: 0.6496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P184T	DO228976	LICA	ICGC	PLPTPVLT	DEG_SCF_FBW7_1	0.0833
p.A177V	DO42673	UCEC	ICGC	PLPTPVLT	DEG_SCF_FBW7_1	0.2778
p.L166W	SIDM00258	Neuroblastoma	GDSC	PLPTPVLT	DEG_SCF_FBW7_1	0.2778
p.A177T	SIDM00333	Endometrial Carcinoma	GDSC	PLPTPVLT	DEG_SCF_FBW7_1	0.2778
p.A177T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PLPTPVLT	DEG_SCF_FBW7_1	0.2778
p.A177T	MFE-319	endometrium	COSMIC	PLPTPVLT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99583	Max-binding protein MNT	DEG_SCF_FBW7_1	168:175	PLPTPVLT	FBXW7	0.9803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons