DegronMD

Uniprot ID: Q99583

Source protein: Max-binding protein MNT

Source gene: MNT

Class: DEG_ODPH_VHL_1

Location: 470:481

E3 ligase: VHL

DEGRON score: 0.9246

ASA_SCORE: 82.3667

COIL: 0.8006

CONS_SCORE: 0.4902

DSS_SCORE: 0.5182

HELIX: 0.0292

FCONS_SCORE: 1.0885

RIG_SCORE: 0.6695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A468T	TCGA-2W-A8YY	CESC	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.2778
p.A468T	TCGA-AA-3864	COAD	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.2778
p.A468T	DO223732	CESC	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.2778
p.A468T	DO8490	COAD	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.2778
p.G489V	TCGA-BQ-7060	KIRP	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.1111
p.G489V	DO20831	KIRP	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.1111
p.G464D	TCGA-D1-A16F	UCEC	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.1667
p.G464D	DO42408	UCEC	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.1667
p.A482V	TCGA-HU-A4GU	STAD	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.3056
p.A482V	DO47849	STAD	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.3056
p.P487H	TCGA-KR-A7K2	LIHC	TCGA	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.1667
p.P487H	DO49697	LIHC	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.1667
p.A471T	DO50090	COAD	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.7139
p.A471T	DO228935	COCA	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.7139
p.A471T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.7139
p.H469N	DO44808	LICA	ICGC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.3056
p.A484V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.25
p.V479L	SIDM00996	Thyroid Gland Carcinoma	GDSC	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.5654
p.V479L	ACH-001307	Thyroid Cancer	CCLE	IAPSAPSPAVQL	DEG_ODPH_VHL_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99583	Max-binding protein MNT	DEG_ODPH_VHL_1	470:481	IAPSAPSPAVQL	VHL	0.9246	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons