DegronMD - Q9UBY0(SLC9A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S665F	TCGA-18-3409	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation blocking phosphorylation signal	0.75
p.S665F	DO26444	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation blocking phosphorylation signal	0.75
p.N673S	TCGA-56-8503	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0833
p.N673S	DO45444	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0833
p.R666Q	TCGA-EB-A44O	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.R666Q	TCGA-GF-A6C9	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.R666Q	DO47272	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.R666Q	DO51254	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.R666Q	SIDM01588	Endometrial Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2778
p.S661F	TCGA-FR-A726	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7982
p.S661F	TCGA-IR-A3LI	CESC	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7982
p.S661F	DO44400	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7982
p.S661F	DO48665	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7982
p.D651N	TCGA-FR-A7U9	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0833
p.D651N	DO48546	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.0833
p.S669F	TCGA-W3-AA1W	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	660:664	Mutation blocking phosphorylation signal	0.6389
p.S669F	DO51277	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation blocking phosphorylation signal	0.6389
p.T674M	DO233272	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation blocking phosphorylation signal	0.5
p.R656L	DO229029	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.K650N	DO229028	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation substituting flanking lysine	0.1667
p.T674A	DO23546	LIRI	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation blocking phosphorylation signal	0.5
p.KD650KN	DO222843	MELA	ICGC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation substituting flanking lysine	0.1111
p.R656Q	SIDM00088	Prostate Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.R656Q	SIDM00908	Non-Cancerous	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.R656Q	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.R656Q	SIDM00265	Ewing's Sarcoma	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.R656Q	SIDM00909	Melanoma	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.R656Q	SIDM00701	Non-Cancerous	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation rewiring degron network	0.2222
p.S663L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7667
p.S663L	ACH-000892	Lung Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7667
p.S663L	NCI-H1563	lung	COSMIC	ASTST	DEG_SPOP_SBC_1	660:664	Mutation altering degron motif	0.7667

Kaplan plot for SLC9A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC9A2

UniProt ID: Q9UBY0

Entrez ID: 6549

Protein name: Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC9A2 in