DegronMD - Q9UNF1(MAGED2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W237L	TCGA-28-1751	GBM	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.3056
p.W237L	DO13743	GBM	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.3056
p.P43L	TCGA-2W-A8YY	CESC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7582
p.P43L	TCGA-59-2349	OV	TCGA	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7582
p.P43L	DO223732	CESC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7582
p.P43L	DO28621	OV	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.7582
p.T549N	TCGA-3A-A9I9	PAAD	TCGA	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2778
p.T549N	DO51679	PAAD	ICGC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.2778
p.A551D	TCGA-56-8307	LUSC	TCGA	ASTST	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7793
p.A551D	DO219139	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation altering degron motif	0.7793
p.R76W	TCGA-63-A5M9	LUSC	TCGA	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1389
p.R76W	DO223726	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1389
p.K44N	TCGA-A5-A1OF	UCEC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.5806
p.K44N	DO42568	UCEC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation altering degron motif	0.5806
p.L243F	TCGA-AJ-A2QO	UCEC	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation altering degron motif	0.587
p.L243F	DO42177	UCEC	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation altering degron motif	0.587
p.E543D	TCGA-AP-A1DV	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1111
p.E543D	DO43186	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1111
p.V55M	TCGA-AX-A1CE	UCEC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.0833
p.V55M	DO233203	GACA	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.0833
p.V55M	DO42280	UCEC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.0833
p.R231M	TCGA-AX-A1CE	UCEC	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.1389
p.R231M	DO42280	UCEC	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.1389
p.K56N	TCGA-D1-A17Q	UCEC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation substituting flanking lysine	0.1667
p.K56N	DO41903	UCEC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation substituting flanking lysine	0.1667
p.Q35K	TCGA-D3-A2JL	SKCM	TCGA	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2222
p.Q35K	DO47278	SKCM	ICGC	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.2222
p.R251H	TCGA-FP-A4BE	STAD	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.1944
p.R251H	DO48016	STAD	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.1944
p.R251H	SIDM00217	Colorectal Carcinoma	GDSC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.1944
p.R251H	ACH-000999	Colon/Colorectal Cancer	CCLE	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.1944
p.R256H	DO233281	GACA	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.0556
p.S247L	DO233653	GACA	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation blocking phosphorylation signal	0.75
p.S247L	DO23528	LIRI	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation blocking phosphorylation signal	0.75
p.A563S	DO229019	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1111
p.S84L	DO233297	NACA	ICGC	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation altering degron motif	0.6556
p.G550C	SIDM00315	Glioblastoma	GDSC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.G550C	ACH-000570	Brain Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.G550A	SIDM00315	Glioblastoma	GDSC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.G550A	ACH-000570	Brain Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.3056
p.A78T	SIDM00583	Pancreatic Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1944
p.A78T	KP-1N	pancreas	COSMIC	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1944
p.A563V	SIDM00537	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1111
p.A563V	ACH-001345	Colon/Colorectal Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1111
p.N36I	ACH-000143	Lung Cancer	CCLE	VPETPKAS	DEG_SCF_FBW7_1	39:46	Mutation rewiring degron network	0.25
p.S562N	ACH-000985	Colon/Colorectal Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	551:555	Mutation rewiring degron network	0.1389
p.P75L	769-P	kidney	COSMIC	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1111
p.V246A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation altering degron motif	0.6936
p.P95L	769-P	kidney	COSMIC	ASSTT	DEG_SPOP_SBC_1	83:87	Mutation rewiring degron network	0.1111
p.R238Q	MCC13	skin	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation altering degron motif	0.7329
p.E234K	HCC2998	large intestine	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation rewiring degron network	0.2222
p.A242S	BB49-HNC	upper aerodigestive tract	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	238:246	Mutation altering degron motif	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGED2

UniProt ID: Q9UNF1

Entrez ID: 10916

Protein name: Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGED2 in