DegronMD

Uniprot ID: Q9UNF1

Source protein: Melanoma-associated antigen D2

Source gene: MAGED2

Class: DEG_SCF_FBW7_1

Location: 39:46

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 86.125

COIL: 0.8438

CONS_SCORE: 0.3732

DSS_SCORE: 0.4727

HELIX: 0.1216

FCONS_SCORE: 1.0431

RIG_SCORE: 0.7358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P43L	TCGA-2W-A8YY	CESC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	0.7582
p.P43L	TCGA-59-2349	OV	TCGA	VPETPKAS	DEG_SCF_FBW7_1	0.7582
p.P43L	DO223732	CESC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.7582
p.P43L	DO28621	OV	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.7582
p.K44N	TCGA-A5-A1OF	UCEC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	0.5806
p.K44N	DO42568	UCEC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.5806
p.V55M	TCGA-AX-A1CE	UCEC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	0.0833
p.V55M	DO233203	GACA	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.0833
p.V55M	DO42280	UCEC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.0833
p.K56N	TCGA-D1-A17Q	UCEC	TCGA	VPETPKAS	DEG_SCF_FBW7_1	0.1667
p.K56N	DO41903	UCEC	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.1667
p.Q35K	TCGA-D3-A2JL	SKCM	TCGA	VPETPKAS	DEG_SCF_FBW7_1	0.2222
p.Q35K	DO47278	SKCM	ICGC	VPETPKAS	DEG_SCF_FBW7_1	0.2222
p.N36I	ACH-000143	Lung Cancer	CCLE	VPETPKAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNF1	Melanoma-associated antigen D2	DEG_SCF_FBW7_1	39:46	VPETPKAS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons