DegronMD

Uniprot ID: Q9UNF1

Source protein: Melanoma-associated antigen D2

Source gene: MAGED2

Class: DEG_APCC_DBOX_1

Location: 238:246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9734

ASA_SCORE: 105.1556

COIL: 0.4873

CONS_SCORE: 0.3506

DSS_SCORE: 0.3595

HELIX: 0.4857

FCONS_SCORE: 1.0001

RIG_SCORE: 0.8084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W237L	TCGA-28-1751	GBM	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	0.3056
p.W237L	DO13743	GBM	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.3056
p.L243F	TCGA-AJ-A2QO	UCEC	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	0.587
p.L243F	DO42177	UCEC	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.587
p.R231M	TCGA-AX-A1CE	UCEC	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	0.1389
p.R231M	DO42280	UCEC	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.1389
p.R251H	TCGA-FP-A4BE	STAD	TCGA	ARRALLSLR	DEG_APCC_DBOX_1	0.1944
p.R251H	DO48016	STAD	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.1944
p.R251H	SIDM00217	Colorectal Carcinoma	GDSC	ARRALLSLR	DEG_APCC_DBOX_1	0.1944
p.R251H	ACH-000999	Colon/Colorectal Cancer	CCLE	ARRALLSLR	DEG_APCC_DBOX_1	0.1944
p.R256H	DO233281	GACA	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.0556
p.S247L	DO233653	GACA	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.75
p.S247L	DO23528	LIRI	ICGC	ARRALLSLR	DEG_APCC_DBOX_1	0.75
p.V246A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	0.6936
p.R238Q	MCC13	skin	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	0.7329
p.E234K	HCC2998	large_intestine	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	0.2222
p.A242S	BB49-HNC	upper_aerodigestive_tract	COSMIC	ARRALLSLR	DEG_APCC_DBOX_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNF1	Melanoma-associated antigen D2	DEG_APCC_DBOX_1	238:246	ARRALLSLR	APC,CDC20,FZR1	0.9734	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons