DegronMD

Uniprot ID: Q96QE4

Source protein: Leucine-rich repeat-containing protein 37B

Source gene: LRRC37B

Class: DEG_SCF_FBW7_1

Location: 451:458

E3 ligase: FBXW7

DEGRON score: 0.564

ASA_SCORE: 88.175

COIL: 0.9343

CONS_SCORE: 0.4696

DSS_SCORE: 0.8379

HELIX: 0.0191

FCONS_SCORE: 0.9157

RIG_SCORE: 0.6321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T459S	TCGA-77-7337	LUSC	TCGA	LAITPEPT	DEG_SCF_FBW7_1	0.3056
p.T459S	DO27445	LUSC	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.3056
p.A466V	TCGA-D7-A6EY	STAD	TCGA	LAITPEPT	DEG_SCF_FBW7_1	0.1111
p.A466V	DO50118	STAD	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.1111
p.L451F	TCGA-D8-A1X9	BRCA	TCGA	LAITPEPT	DEG_SCF_FBW7_1	0.6981
p.R461H	DO219915	DLBC	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.25
p.Q445H	DO228952	LICA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.1667
p.T448N	DO228974	LICA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.25
p.I453T	DO220883	MELA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.5966
p.T465K	DO232018	ORCA	ICGC	LAITPEPT	DEG_SCF_FBW7_1	0.1389
p.E460D	SIDM01267	Non-Cancerous	GDSC	LAITPEPT	DEG_SCF_FBW7_1	0.2778
p.E468K	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.0556
p.E441K	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.0556
p.L446V	NCI-H2342	lung	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.1944
p.G445R	SK-LU-1	lung	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.1667
p.E452D	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.6758
p.E467D	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.0833
p.P464L	NCI-H1734	lung	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.1667
p.E453K	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LAITPEPT	DEG_SCF_FBW7_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QE4	Leucine-rich repeat-containing protein 37B	DEG_SCF_FBW7_1	451:458	LAITPEPT	FBXW7	0.564	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons