DegronMD

Uniprot ID: Q6K0P9

Source protein: Pyrin and HIN domain-containing protein 1

Source gene: PYHIN1

Class: DEG_SCF_FBW7_1

Location: 114:120

E3 ligase: FBXW7

DEGRON score: 0.9963

ASA_SCORE: 81.1714

COIL: 0.9301

CONS_SCORE: 0.7177

DSS_SCORE: 0.5648

HELIX: 0.0259

FCONS_SCORE: 1.2778

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P114S	TCGA-18-3409	LUSC	TCGA	PATPACT	DEG_SCF_FBW7_1	0.6752
p.P114S	DO26444	LUSC	ICGC	PATPACT	DEG_SCF_FBW7_1	0.6752
p.T107M	TCGA-A5-A0G2	UCEC	TCGA	PATPACT	DEG_SCF_FBW7_1	0.1389
p.T107M	DO218709	BRCA	ICGC	PATPACT	DEG_SCF_FBW7_1	0.1389
p.T107M	DO230341	COCA	ICGC	PATPACT	DEG_SCF_FBW7_1	0.1389
p.T107M	DO41235	UCEC	ICGC	PATPACT	DEG_SCF_FBW7_1	0.1389
p.T126A	TCGA-AA-3713	COAD	TCGA	PATPACT	DEG_SCF_FBW7_1	0.1667
p.T126A	DO8400	COAD	ICGC	PATPACT	DEG_SCF_FBW7_1	0.1667
p.S122R	TCGA-BR-8372	STAD	TCGA	PATPACT	DEG_SCF_FBW7_1	0.2778
p.S122R	DO47873	STAD	ICGC	PATPACT	DEG_SCF_FBW7_1	0.2778
p.A118V	TCGA-CG-4306	STAD	TCGA	PATPACT	DEG_SCF_FBW7_1	0.5825
p.A118V	DO38567	STAD	ICGC	PATPACT	DEG_SCF_FBW7_1	0.5825
p.G129E	TCGA-D3-A3CB	SKCM	TCGA	PATPACT	DEG_SCF_FBW7_1	0.0833
p.G129E	DO47386	SKCM	ICGC	PATPACT	DEG_SCF_FBW7_1	0.0833
p.P117T	DO233716	GACA	ICGC	PATPACT	DEG_SCF_FBW7_1	0.7031
p.Q109P	DO233918	GACA	ICGC	PATPACT	DEG_SCF_FBW7_1	0.1944
p.K108R	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	PATPACT	DEG_SCF_FBW7_1	0.2778
p.K108R	ACH-001363	Lung Cancer	CCLE	PATPACT	DEG_SCF_FBW7_1	0.2778
p.K108R	NCI-H2135	lung	COSMIC	PATPACT	DEG_SCF_FBW7_1	0.2778
p.Q109R	SIDM00498	Colorectal Carcinoma	GDSC	PATPACT	DEG_SCF_FBW7_1	0.1944
p.Q109R	ACH-000970	Colon/Colorectal Cancer	CCLE	PATPACT	DEG_SCF_FBW7_1	0.1944
p.Q109R	SNU-C5	large_intestine	COSMIC	PATPACT	DEG_SCF_FBW7_1	0.1944
p.V112L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PATPACT	DEG_SCF_FBW7_1	0.2778
p.V112L	ACH-000589	Lung Cancer	CCLE	PATPACT	DEG_SCF_FBW7_1	0.2778
p.V112L	NCI-H1437	lung	COSMIC	PATPACT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SCF_FBW7_1	114:120	PATPACT	FBXW7	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons