DegronMD - Q8IYD1(GSPT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E182G	TCGA-AA-3968	COAD	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.1389
p.E182G	DO9178	COAD	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.1389
p.V194I	TCGA-AP-A051	UCEC	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7076
p.V194I	DO222655	BTCA	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7076
p.V194I	DO42673	UCEC	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7076
p.K201T	TCGA-AX-A1CE	UCEC	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation substituting flanking lysine	0.3611
p.K201T	DO42280	UCEC	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation substituting flanking lysine	0.3611
p.K183E	TCGA-BR-8297	STAD	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation substituting flanking lysine	0.2778
p.K183E	DO38555	STAD	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation substituting flanking lysine	0.2778
p.V206I	TCGA-CK-6751	COAD	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.1111
p.V206I	DO10340	COAD	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.1111
p.E184D	TCGA-D5-6927	COAD	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.1944
p.E184D	DO10332	COAD	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.1944
p.C14Y	TCGA-DF-A2KN	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.1667
p.C14Y	DO223282	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.1667
p.S3L	TCGA-E6-A1LX	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation altering degron motif	0.8778
p.S3L	DO41020	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation altering degron motif	0.8778
p.S3L	SIDM01619	Endometrial Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation altering degron motif	0.8778
p.S3L	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation altering degron motif	0.8778
p.F208V	TCGA-EY-A1GD	UCEC	TCGA	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.0556
p.F208V	DO42129	UCEC	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.0556
p.S196L	DO218176	BRCA	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.8778
p.D16N	DO227999	COCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.1111
p.G4D	DO50970	LICA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation altering degron motif	0.7198
p.M180T	DO23198	LINC	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.0833
p.V18E	DO222880	MELA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.0556
p.A198S	DO50726	ORCA	ICGC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7588
p.A11V	DO228142	PBCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.25
p.S189C	SIDM01265	Plasma Cell Myeloma	GDSC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7541
p.S189C	ACH-000763	Myeloma	CCLE	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7541
p.S189C	MM1S	haematopoietic and lymphoid tissue	COSMIC	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation altering degron motif	0.7541
p.S10L	SIDM01617	Endometrial Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.2778
p.S10L	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.2778
p.D9N	ACH-000809	Esophageal Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.3056
p.Q17R	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	2:8	Mutation rewiring degron network	0.0833
p.E185K	ACH-001521	Skin Cancer	CCLE	SKSVIVPSGA	DEG_COP1_1	189:198	Mutation rewiring degron network	0.2222

Kaplan plot for GSPT2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GSPT2

UniProt ID: Q8IYD1

Entrez ID: 23708

Protein name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GSPT2 in