DegronMD

Uniprot ID: Q8IYD1

Source protein: Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Source gene: GSPT2

Class: DEG_COP1_1

Location: 189:198

E3 ligase: COP1

DEGRON score: 0.9924

ASA_SCORE: 78.4

COIL: 0.842

CONS_SCORE: 0.2204

DSS_SCORE: 0.5422

HELIX: 0.0954

FCONS_SCORE: 0.6207

RIG_SCORE: 0.6861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E182G	TCGA-AA-3968	COAD	TCGA	SKSVIVPSGA	DEG_COP1_1	0.1389
p.E182G	DO9178	COAD	ICGC	SKSVIVPSGA	DEG_COP1_1	0.1389
p.V194I	TCGA-AP-A051	UCEC	TCGA	SKSVIVPSGA	DEG_COP1_1	0.7076
p.V194I	DO222655	BTCA	ICGC	SKSVIVPSGA	DEG_COP1_1	0.7076
p.V194I	DO42673	UCEC	ICGC	SKSVIVPSGA	DEG_COP1_1	0.7076
p.K201T	TCGA-AX-A1CE	UCEC	TCGA	SKSVIVPSGA	DEG_COP1_1	0.3611
p.K201T	DO42280	UCEC	ICGC	SKSVIVPSGA	DEG_COP1_1	0.3611
p.K183E	TCGA-BR-8297	STAD	TCGA	SKSVIVPSGA	DEG_COP1_1	0.2778
p.K183E	DO38555	STAD	ICGC	SKSVIVPSGA	DEG_COP1_1	0.2778
p.V206I	TCGA-CK-6751	COAD	TCGA	SKSVIVPSGA	DEG_COP1_1	0.1111
p.V206I	DO10340	COAD	ICGC	SKSVIVPSGA	DEG_COP1_1	0.1111
p.E184D	TCGA-D5-6927	COAD	TCGA	SKSVIVPSGA	DEG_COP1_1	0.1944
p.E184D	DO10332	COAD	ICGC	SKSVIVPSGA	DEG_COP1_1	0.1944
p.F208V	TCGA-EY-A1GD	UCEC	TCGA	SKSVIVPSGA	DEG_COP1_1	0.0556
p.F208V	DO42129	UCEC	ICGC	SKSVIVPSGA	DEG_COP1_1	0.0556
p.S196L	DO218176	BRCA	ICGC	SKSVIVPSGA	DEG_COP1_1	0.8778
p.M180T	DO23198	LINC	ICGC	SKSVIVPSGA	DEG_COP1_1	0.0833
p.A198S	DO50726	ORCA	ICGC	SKSVIVPSGA	DEG_COP1_1	0.7588
p.S189C	SIDM01265	Plasma Cell Myeloma	GDSC	SKSVIVPSGA	DEG_COP1_1	0.7541
p.S189C	ACH-000763	Myeloma	CCLE	SKSVIVPSGA	DEG_COP1_1	0.7541
p.S189C	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	SKSVIVPSGA	DEG_COP1_1	0.7541
p.E185K	ACH-001521	Skin Cancer	CCLE	SKSVIVPSGA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYD1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	DEG_COP1_1	189:198	SKSVIVPSGA	COP1	0.9924	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons