DegronMD

Uniprot ID: Q8IYD1

Source protein: Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Source gene: GSPT2

Class: DEG_SCF_TRCP1_1

Location: 2:8

E3 ligase: BTRC

DEGRON score: 0.8884

ASA_SCORE: 86.5571

COIL: 0.9367

CONS_SCORE: 0.1654

DSS_SCORE: 0.9033

HELIX: 0.057

FCONS_SCORE: 0.8091

RIG_SCORE: 0.5378

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C14Y	TCGA-DF-A2KN	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.1667
p.C14Y	DO223282	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.1667
p.S3L	TCGA-E6-A1LX	UCEC	TCGA	DSGSSSS	DEG_SCF_TRCP1_1	0.8778
p.S3L	DO41020	UCEC	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.8778
p.S3L	SIDM01619	Endometrial Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	0.8778
p.S3L	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	0.8778
p.D16N	DO227999	COCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.1111
p.G4D	DO50970	LICA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.7198
p.V18E	DO222880	MELA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.0556
p.A11V	DO228142	PBCA	ICGC	DSGSSSS	DEG_SCF_TRCP1_1	0.25
p.S10L	SIDM01617	Endometrial Carcinoma	GDSC	DSGSSSS	DEG_SCF_TRCP1_1	0.2778
p.S10L	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	0.2778
p.D9N	ACH-000809	Esophageal Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	0.3056
p.Q17R	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGSSSS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SCF_TRCP1_1	495:501	DSGSSSS	BTRC	0.9422	More...
Q8IYD1	Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	DEG_SCF_TRCP1_1	2:8	DSGSSSS	BTRC	0.8884	More...
Q8NFP9	Neurobeachin	DEG_SCF_TRCP1_1	1844:1850	DSGSSSS	BTRC	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons