DegronMD

Uniprot ID: Q8NFP9

Source protein: Neurobeachin

Source gene: NBEA

Class: DEG_SPOP_SBC_1

Location: 1140:1144

E3 ligase: SPOP

DEGRON score: 0.9729

ASA_SCORE: 77.5

COIL: 0.8572

CONS_SCORE: 0.2984

DSS_SCORE: 0.4561

HELIX: 0.1144

FCONS_SCORE: 1.0103

RIG_SCORE: 0.6732

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1131K	TCGA-AF-A56L	READ	TCGA	PNSST	DEG_SPOP_SBC_1	0.0833
p.T1131K	DO50276	READ	ICGC	PNSST	DEG_SPOP_SBC_1	0.0833
p.E1137D	TCGA-AY-4070	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.25
p.E1137D	DO10518	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.25
p.A1133E	TCGA-CM-6676	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.1389
p.A1133E	DO9546	COAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.1389
p.N1141S	TCGA-D3-A2JF	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	0.5958
p.N1141S	DO38153	SKCM	ICGC	PNSST	DEG_SPOP_SBC_1	0.5958
p.S1143G	TCGA-EO-A22R	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.6993
p.S1143G	DO42713	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.6993
p.D1138Y	TCGA-F5-6814	READ	TCGA	PNSST	DEG_SPOP_SBC_1	0.2778
p.D1138Y	DO36556	READ	ICGC	PNSST	DEG_SPOP_SBC_1	0.2778
p.D1149H	TCGA-G5-6233	READ	TCGA	PNSST	DEG_SPOP_SBC_1	0.1944
p.D1149H	DO36626	READ	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.A1133V	DO227786	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1389
p.E1135K	DO220877	MELA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.N1141I	SIDM00545	Melanoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.6169
p.N1141I	ACH-000987	Skin Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.6169
p.N1141I	Mewo	skin	COSMIC	PNSST	DEG_SPOP_SBC_1	0.6169
p.L1147I	SIDM00118	Colorectal Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.25
p.L1147I	SIDM01611	Endometrial Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.25
p.L1147I	ACH-000996	Endometrial/Uterine Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.25
p.L1147I	ACH-001081	Colon/Colorectal Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.25
p.L1147I	HCC2998	large_intestine	COSMIC	PNSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons