DegronMD

Uniprot ID: P78536

Source protein: Disintegrin and metalloproteinase domain-containing protein 17

Source gene: ADAM17

Class: DEG_SPOP_SBC_1

Location: 783:787

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 78.34

COIL: 0.8868

CONS_SCORE: 0.296

DSS_SCORE: 0.616

HELIX: 0.0886

FCONS_SCORE: 0.9948

RIG_SCORE: 0.6123

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A789P	TCGA-30-1857	OV	TCGA	PNSST	DEG_SPOP_SBC_1	0.2778
p.A789P	DO28491	OV	ICGC	PNSST	DEG_SPOP_SBC_1	0.2778
p.E778Q	TCGA-97-A4M3	LUAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.1944
p.E778Q	TCGA-ZF-A9RD	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	0.1944
p.E778Q	DO219070	BLCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.E778Q	DO218937	LUAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.F792L	TCGA-97-A4M7	LUAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.1944
p.F792L	DO45386	LUAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.T796M	TCGA-DD-A3A7	LIHC	TCGA	PNSST	DEG_SPOP_SBC_1	0.5278
p.T796M	DO44982	LIHC	ICGC	PNSST	DEG_SPOP_SBC_1	0.5278
p.T796M	SIDM00180	Kidney Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.5278
p.T796M	SIDM01645	Non-Cancerous	GDSC	PNSST	DEG_SPOP_SBC_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons