DegronMD - Q92547(TOPBP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1008W	TCGA-37-4130	LUSC	TCGA	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.0833
p.R1008W	TCGA-B5-A11Y	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.0833
p.R1008W	DO26490	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.0833
p.R1008W	DO40889	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.0833
p.D543N	TCGA-78-7146	LUAD	TCGA	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.6932
p.D543N	DO23717	LUAD	ICGC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.6932
p.S528Y	TCGA-A5-A0G2	UCEC	TCGA	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation rewiring degron network	0.1389
p.S528Y	DO41235	UCEC	ICGC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation rewiring degron network	0.1389
p.P299H	TCGA-A5-A0G2	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.P299H	DO41235	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.P859L	TCGA-A5-A1OF	UCEC	TCGA	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.6471
p.P859L	DO42568	UCEC	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.6471
p.N870T	TCGA-A5-A2K5	UCEC	TCGA	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.1944
p.N870T	DO41379	UCEC	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.1944
p.D307N	TCGA-BL-A5ZZ	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.D307N	DO44027	BLCA	ICGC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.T861M	TCGA-BR-4184	STAD	TCGA	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.8534
p.T861M	TCGA-F4-6856	COAD	TCGA	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.8534
p.T861M	DO9114	COAD	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.8534
p.T861M	DO38328	STAD	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.8534
p.P542T	TCGA-D3-A1QA	SKCM	TCGA	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.7031
p.P542T	DO229032	LICA	ICGC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.7031
p.P542T	DO47469	SKCM	ICGC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.7031
p.P542H	TCGA-DA-A1I1	SKCM	TCGA	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.7694
p.P542H	DO37966	SKCM	ICGC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.7694
p.P286H	TCGA-EE-A183	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.P286H	DO37715	SKCM	ICGC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.A874V	TCGA-EI-6917	READ	TCGA	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.0833
p.A874V	DO36881	READ	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.0833
p.V866F	TCGA-VS-A950	CESC	TCGA	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.3056
p.V866F	DO51635	CESC	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.3056
p.V868I	DO50346	ESAD	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.25
p.R1013G	DO233232	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2222
p.P849S	DO11854	GBM	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.0556
p.N304K	DO229029	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1667
p.P1026Q	DO229028	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.P1026T	DO229025	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1944
p.T300N	DO229036	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation blocking phosphorylation signal	0.7222
p.S860N	DO50970	LICA	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation altering degron motif	0.7069
p.I867M	DO23532	LIRI	ICGC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.2778
p.D1027G	DO222484	MELA	ICGC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.1667
p.N533T	DO232224	PBCA	ICGC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation rewiring degron network	0.2778
p.E285K	DO228764	PRAD	ICGC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833
p.P299R	SIDM01104	Melanoma	GDSC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.P299R	ACH-000640	Skin Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.P299R	SK-MEL-31	skin	COSMIC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.3056
p.P542S	SIDM00988	Kidney Carcinoma	GDSC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.6752
p.P542S	ACH-000792	Kidney Cancer	CCLE	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.6752
p.P542S	BFTC-909	kidney	COSMIC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.6752
p.N295S	SIDM00079	Ovarian Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.5958
p.N295S	ACH-000811	Ovarian Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.5958
p.N295S	SK-OV-3	ovary	COSMIC	PNSST	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.5958
p.D1023N	SIDM00225	Melanoma	GDSC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2778
p.D1023N	ACH-002143	Skin Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2778
p.D1023N	IST-MEL1	skin	COSMIC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation rewiring degron network	0.2778
p.D1018N	IST-MEL1	skin	COSMIC	AVSST	DEG_SPOP_SBC_1	1017:1021	Mutation altering degron motif	0.6932
p.P537S	BFTC-909	kidney	COSMIC	SSVSHCVPDV	DEG_COP1_1	535:544	Mutation altering degron motif	0.6752
p.N872S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.1389
p.A871V	CW-2	large intestine	COSMIC	PSTPLSE	DEG_SCF_FBW7_2	859:865	Mutation rewiring degron network	0.1667

Kaplan plot for TOPBP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOPBP1

UniProt ID: Q92547

Entrez ID: 11073

Protein name: DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOPBP1 in