DegronMD

Uniprot ID: Q92547

Source protein: DNA topoisomerase 2-binding protein 1

Source gene: TOPBP1

Class: DEG_COP1_1

Location: 535:544

E3 ligase: COP1

DEGRON score: 0.9388

ASA_SCORE: 69.84

COIL: 0.6854

CONS_SCORE: 0.2631

DSS_SCORE: 0.4612

HELIX: 0.0787

FCONS_SCORE: 0.9064

RIG_SCORE: 0.718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D543N	TCGA-78-7146	LUAD	TCGA	SSVSHCVPDV	DEG_COP1_1	0.6932
p.D543N	DO23717	LUAD	ICGC	SSVSHCVPDV	DEG_COP1_1	0.6932
p.S528Y	TCGA-A5-A0G2	UCEC	TCGA	SSVSHCVPDV	DEG_COP1_1	0.1389
p.S528Y	DO41235	UCEC	ICGC	SSVSHCVPDV	DEG_COP1_1	0.1389
p.P542T	TCGA-D3-A1QA	SKCM	TCGA	SSVSHCVPDV	DEG_COP1_1	0.7031
p.P542T	DO229032	LICA	ICGC	SSVSHCVPDV	DEG_COP1_1	0.7031
p.P542T	DO47469	SKCM	ICGC	SSVSHCVPDV	DEG_COP1_1	0.7031
p.P542H	TCGA-DA-A1I1	SKCM	TCGA	SSVSHCVPDV	DEG_COP1_1	0.7694
p.P542H	DO37966	SKCM	ICGC	SSVSHCVPDV	DEG_COP1_1	0.7694
p.N533T	DO232224	PBCA	ICGC	SSVSHCVPDV	DEG_COP1_1	0.2778
p.P542S	SIDM00988	Kidney Carcinoma	GDSC	SSVSHCVPDV	DEG_COP1_1	0.6752
p.P542S	ACH-000792	Kidney Cancer	CCLE	SSVSHCVPDV	DEG_COP1_1	0.6752
p.P542S	BFTC-909	kidney	COSMIC	SSVSHCVPDV	DEG_COP1_1	0.6752
p.P537S	BFTC-909	kidney	COSMIC	SSVSHCVPDV	DEG_COP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92547	DNA topoisomerase 2-binding protein 1	DEG_COP1_1	535:544	SSVSHCVPDV	COP1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons