DegronMD

Uniprot ID: Q92547

Source protein: DNA topoisomerase 2-binding protein 1

Source gene: TOPBP1

Class: DEG_SPOP_SBC_1

Location: 294:298

E3 ligase: SPOP

DEGRON score: 0.9767

ASA_SCORE: 85.82

COIL: 0.952

CONS_SCORE: 0.3133

DSS_SCORE: 0.6876

HELIX: 0.024

FCONS_SCORE: 1.2121

RIG_SCORE: 0.6099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P299H	TCGA-A5-A0G2	UCEC	TCGA	PNSST	DEG_SPOP_SBC_1	0.3056
p.P299H	DO41235	UCEC	ICGC	PNSST	DEG_SPOP_SBC_1	0.3056
p.D307N	TCGA-BL-A5ZZ	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	0.0833
p.D307N	DO44027	BLCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.0833
p.P286H	TCGA-EE-A183	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	0.1111
p.P286H	DO37715	SKCM	ICGC	PNSST	DEG_SPOP_SBC_1	0.1111
p.N304K	DO229029	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1667
p.T300N	DO229036	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	0.7222
p.E285K	DO228764	PRAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.0833
p.P299R	SIDM01104	Melanoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.3056
p.P299R	ACH-000640	Skin Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.3056
p.P299R	SK-MEL-31	skin	COSMIC	PNSST	DEG_SPOP_SBC_1	0.3056
p.N295S	SIDM00079	Ovarian Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.5958
p.N295S	ACH-000811	Ovarian Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.5958
p.N295S	SK-OV-3	ovary	COSMIC	PNSST	DEG_SPOP_SBC_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons