DegronMD

Uniprot ID: Q9ULT6

Source protein: E3 ubiquitin-protein ligase ZNRF3

Source gene: ZNRF3

Class: DEG_SPOP_SBC_1

Location: 678:682

E3 ligase: SPOP

DEGRON score: 0.7312

ASA_SCORE: 82.48

COIL: 0.8618

CONS_SCORE: 0.3146

DSS_SCORE: 0.6467

HELIX: 0.0754

FCONS_SCORE: 0.7624

RIG_SCORE: 0.553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S683L	TCGA-22-5491	LUSC	TCGA	PNSST	DEG_SPOP_SBC_1	0.3056
p.S683L	TCGA-DK-AA75	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	0.3056
p.P678H	TCGA-D3-A1Q3	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	0.7694
p.L687F	TCGA-FW-A3R5	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	0.1944
p.S671F	TCGA-W3-AA1V	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	0.1389
p.P678S	DO5521	BRCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.6752
p.G692R	DO230343	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.0556
p.R689H	DO228041	EOPC	ICGC	PNSST	DEG_SPOP_SBC_1	0.1389
p.K673R	DO233109	GACA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.V687M	DO229453	SKCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1944
p.E683A	DO222328	STAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.3056
p.L687R	SIDM00567	Other Solid Cancers	GDSC	PNSST	DEG_SPOP_SBC_1	0.1944
p.L687R	ACH-000776	Brain Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.1944
p.L687R	ONS-76	central_nervous_system	COSMIC	PNSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons