DegronMD

Uniprot ID: Q5VT52

Source protein: Regulation of nuclear pre-mRNA domain-containing protein 2

Source gene: RPRD2

Class: DEG_SPOP_SBC_1

Location: 594:598

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 90.84

COIL: 0.9618

CONS_SCORE: 0.3652

DSS_SCORE: 0.465

HELIX: 0.0202

FCONS_SCORE: 1.0438

RIG_SCORE: 0.5796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S599Y	TCGA-06-5416	GBM	TCGA	PNSST	DEG_SPOP_SBC_1	0.3056
p.P587T	TCGA-CA-6717	COAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.1389
p.Y592C	TCGA-CV-A6K1	HNSC	TCGA	PNSST	DEG_SPOP_SBC_1	0.7222
p.P594H	TCGA-EE-A3AA	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	0.7694
p.K588R	TCGA-N5-A4RD	UCS	TCGA	PNSST	DEG_SPOP_SBC_1	0.2778
p.T595A	DO233663	GACA	ICGC	PNSST	DEG_SPOP_SBC_1	0.7139
p.P594L	SIDM00967	Ovarian Carcinoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.7582
p.P594L	ACH-002181	Ovarian Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	0.7582
p.P594L	OVCA420	ovary	COSMIC	PNSST	DEG_SPOP_SBC_1	0.7582
p.S593N	TOV-21G	ovary	COSMIC	PNSST	DEG_SPOP_SBC_1	0.75
p.S600F	KYSE-270	oesophagus	COSMIC	PNSST	DEG_SPOP_SBC_1	0.2778
p.T606A	CAL-29	urinary_tract	COSMIC	PNSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons