DegronMD

Uniprot ID: Q8WV28

Source protein: B-cell linker protein

Source gene: BLNK

Class: DEG_SPOP_SBC_1

Location: 212:216

E3 ligase: SPOP

DEGRON score: 0.9611

ASA_SCORE: 91.68

COIL: 0.9744

CONS_SCORE: 0.3742

DSS_SCORE: 0.7348

HELIX: 0.0118

FCONS_SCORE: 0.9637

RIG_SCORE: 0.5051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P217S	TCGA-CG-5726	STAD	TCGA	PNSST	DEG_SPOP_SBC_1	0.3056
p.P217S	DO38483	STAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.3056
p.A218T	TCGA-KU-A66S	HNSC	TCGA	PNSST	DEG_SPOP_SBC_1	0.2778
p.A218T	DO225349	BRCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.2778
p.A218T	DO234174	ESAD	ICGC	PNSST	DEG_SPOP_SBC_1	0.2778
p.A218T	DO44456	HNSC	ICGC	PNSST	DEG_SPOP_SBC_1	0.2778
p.A218T	SIDM00202	Ewing's Sarcoma	GDSC	PNSST	DEG_SPOP_SBC_1	0.2778
p.A218T	EW-3	bone	COSMIC	PNSST	DEG_SPOP_SBC_1	0.2778
p.P212T	DO229025	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	0.7031
p.T223K	DO229045	LICA	ICGC	PNSST	DEG_SPOP_SBC_1	0.1389
p.P217L	DO229459	SKCA	ICGC	PNSST	DEG_SPOP_SBC_1	0.3056
p.I203M	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PNSST	DEG_SPOP_SBC_1	0.0833
p.R204Q	K2	skin	COSMIC	PNSST	DEG_SPOP_SBC_1	0.1111
p.R204Q	KS-1	central_nervous_system	COSMIC	PNSST	DEG_SPOP_SBC_1	0.1111
p.R204Q	MZ7-mel	skin	COSMIC	PNSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78536	Disintegrin and metalloproteinase domain-containing protein 17	DEG_SPOP_SBC_1	783:787	PNSST	SPOP	0.9977	More...
Q05397	Focal adhesion kinase 1	DEG_SPOP_SBC_1	14:18	PNSST	SPOP	0.8344	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	594:598	PNSST	SPOP	0.9968	More...
Q659C4	La-related protein 1B	DEG_SPOP_SBC_1	876:880	PNSST	SPOP	0.9535	More...
Q8NFP9	Neurobeachin	DEG_SPOP_SBC_1	1140:1144	PNSST	SPOP	0.9729	More...
Q8WV28	B-cell linker protein	DEG_SPOP_SBC_1	212:216	PNSST	SPOP	0.9611	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	294:298	PNSST	SPOP	0.9767	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	678:682	PNSST	SPOP	0.7312	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	531:535	PNSST	SPOP	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons