DegronMD

Uniprot ID: Q92547

Source protein: DNA topoisomerase 2-binding protein 1

Source gene: TOPBP1

Class: DEG_SPOP_SBC_1

Location: 1017:1021

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 79.96

COIL: 0.8738

CONS_SCORE: 0.2837

DSS_SCORE: 0.5061

HELIX: 0.0828

FCONS_SCORE: 1.0513

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1008W	TCGA-37-4130	LUSC	TCGA	AVSST	DEG_SPOP_SBC_1	0.0833
p.R1008W	TCGA-B5-A11Y	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	0.0833
p.R1008W	DO26490	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.R1008W	DO40889	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.R1013G	DO233232	GACA	ICGC	AVSST	DEG_SPOP_SBC_1	0.2222
p.P1026Q	DO229028	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1944
p.P1026T	DO229025	LICA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1944
p.D1027G	DO222484	MELA	ICGC	AVSST	DEG_SPOP_SBC_1	0.1667
p.D1023N	SIDM00225	Melanoma	GDSC	AVSST	DEG_SPOP_SBC_1	0.2778
p.D1023N	ACH-002143	Skin Cancer	CCLE	AVSST	DEG_SPOP_SBC_1	0.2778
p.D1023N	IST-MEL1	skin	COSMIC	AVSST	DEG_SPOP_SBC_1	0.2778
p.D1018N	IST-MEL1	skin	COSMIC	AVSST	DEG_SPOP_SBC_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons