DegronMD

Uniprot ID: Q9BX66

Source protein: Sorbin and SH3 domain-containing protein 1

Source gene: SORBS1

Class: DEG_SPOP_SBC_1

Location: 266:270

E3 ligase: SPOP

DEGRON score: 0.99

ASA_SCORE: 72.68

COIL: 0.8684

CONS_SCORE: 0.4582

DSS_SCORE: 0.6034

HELIX: 0.0328

FCONS_SCORE: 0.9416

RIG_SCORE: 0.6572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R256H	TCGA-AX-A0J1	UCEC	TCGA	AVSST	DEG_SPOP_SBC_1	0.0556
p.R256H	DO41199	UCEC	ICGC	AVSST	DEG_SPOP_SBC_1	0.0556
p.S259L	TCGA-BR-8363	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.5833
p.S259L	DO47837	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.5833
p.S269C	TCGA-CR-7389	HNSC	TCGA	AVSST	DEG_SPOP_SBC_1	0.7541
p.S269C	DO14190	HNSC	ICGC	AVSST	DEG_SPOP_SBC_1	0.7541
p.R256C	TCGA-CV-5436	HNSC	TCGA	AVSST	DEG_SPOP_SBC_1	0.0556
p.R256C	DO15006	HNSC	ICGC	AVSST	DEG_SPOP_SBC_1	0.0556
p.R257T	TCGA-DR-A0ZM	CESC	TCGA	AVSST	DEG_SPOP_SBC_1	0.0833
p.R257T	DO6254	CESC	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833
p.G265R	TCGA-NC-A5HN	LUSC	TCGA	AVSST	DEG_SPOP_SBC_1	0.3056
p.G265R	DO52025	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	0.3056
p.V280L	DO219209	LUSC	ICGC	AVSST	DEG_SPOP_SBC_1	0.0556
p.R267C	DO220910	MELA	ICGC	AVSST	DEG_SPOP_SBC_1	0.8301
p.S270T	DO37372	READ	ICGC	AVSST	DEG_SPOP_SBC_1	0.7116
p.L263I	DO37410	SKCM	ICGC	AVSST	DEG_SPOP_SBC_1	0.25
p.D258Y	NCI-H1734	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.1111
p.T278N	SNU-1040	large_intestine	COSMIC	AVSST	DEG_SPOP_SBC_1	0.1111
p.Q270H	NCI-H1651	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.7582
p.S264L	BICR22	upper_aerodigestive_tract	COSMIC	AVSST	DEG_SPOP_SBC_1	0.7222
p.S264A	SNU-81	large_intestine	COSMIC	AVSST	DEG_SPOP_SBC_1	0.7222
p.I276T	FADU	upper_aerodigestive_tract	COSMIC	AVSST	DEG_SPOP_SBC_1	0.1667
p.A268T	EoL-1-cell	haematopoietic_and_lymphoid_tissue	COSMIC	AVSST	DEG_SPOP_SBC_1	0.7139
p.D268Y	NCI-H1734	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.7325
p.D271Y	NCI-H1651	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.3056
p.I275T	FADU	upper_aerodigestive_tract	COSMIC	AVSST	DEG_SPOP_SBC_1	0.1944
p.D259Y	NCI-H1734	lung	COSMIC	AVSST	DEG_SPOP_SBC_1	0.5833
p.K278N	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	AVSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVSST

Degron related mutations and impact score

Drug responses associated with SORBS1 mutations

All proteins holding degron of AVSST