DegronMD

Uniprot ID: P10914

Source protein: Interferon regulatory factor 1

Source gene: IRF1

Class: DEG_SPOP_SBC_1

Location: 187:191

E3 ligase: SPOP

DEGRON score: 0.9982

ASA_SCORE: 67.06

COIL: 0.8158

CONS_SCORE: 0.3914

DSS_SCORE: 0.281

HELIX: 0.0966

FCONS_SCORE: 1.2006

RIG_SCORE: 0.7384

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G187R	HCT-15	large_intestine	COSMIC	AVSST	DEG_SPOP_SBC_1	0.7568
p.D194V	TCGA-BR-7704	STAD	TCGA	AVSST	DEG_SPOP_SBC_1	0.25
p.D194V	DO38360	STAD	ICGC	AVSST	DEG_SPOP_SBC_1	0.25
p.E200D	TCGA-AB-2940	LAML	TCGA	AVSST	DEG_SPOP_SBC_1	0.0833
p.E200D	DO21773	LAML	ICGC	AVSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 5 of 5 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	377:381	AVSST	SPOP	0.9866	More...
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SPOP_SBC_1	1017:1021	AVSST	SPOP	0.9996	More...
P10914	Interferon regulatory factor 1	DEG_SPOP_SBC_1	187:191	AVSST	SPOP	0.9982	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1756:1760	AVSST	SPOP	0.8694	More...
Q7Z5N4	Protein sidekick-1	DEG_SPOP_SBC_1	1287:1291	AVSST	SPOP	0.6155	More...
Q15052	Rho guanine nucleotide exchange factor 6	DEG_SPOP_SBC_1	138:142	AVSST	SPOP	0.9973	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	266:270	AVSST	SPOP	0.99	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	422:426	AVSST	SPOP	0.971	More...
Q9GZV5	WW domain-containing transcription regulator protein 1	DEG_SPOP_SBC_1	171:175	AVSST	SPOP	0.9911	More...
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	361:365	AVSST	SPOP	0.9871	More...

Showing 1 to 10 of 10 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons