DegronMD

Uniprot ID: Q92547

Source protein: DNA topoisomerase 2-binding protein 1

Source gene: TOPBP1

Class: DEG_SCF_FBW7_2

Location: 859:865

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 77.2

COIL: 0.7367

CONS_SCORE: 0.3441

DSS_SCORE: 0.5357

HELIX: 0.2164

FCONS_SCORE: 1.1014

RIG_SCORE: 0.7033

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P859L	TCGA-A5-A1OF	UCEC	TCGA	PSTPLSE	DEG_SCF_FBW7_2	0.6471
p.P859L	DO42568	UCEC	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.6471
p.N870T	TCGA-A5-A2K5	UCEC	TCGA	PSTPLSE	DEG_SCF_FBW7_2	0.1944
p.N870T	DO41379	UCEC	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.1944
p.T861M	TCGA-BR-4184	STAD	TCGA	PSTPLSE	DEG_SCF_FBW7_2	0.8534
p.T861M	TCGA-F4-6856	COAD	TCGA	PSTPLSE	DEG_SCF_FBW7_2	0.8534
p.T861M	DO9114	COAD	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.8534
p.T861M	DO38328	STAD	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.8534
p.A874V	TCGA-EI-6917	READ	TCGA	PSTPLSE	DEG_SCF_FBW7_2	0.0833
p.A874V	DO36881	READ	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.0833
p.V866F	TCGA-VS-A950	CESC	TCGA	PSTPLSE	DEG_SCF_FBW7_2	0.3056
p.V866F	DO51635	CESC	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.3056
p.V868I	DO50346	ESAD	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.25
p.P849S	DO11854	GBM	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.0556
p.S860N	DO50970	LICA	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.7069
p.I867M	DO23532	LIRI	ICGC	PSTPLSE	DEG_SCF_FBW7_2	0.2778
p.N872S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPLSE	DEG_SCF_FBW7_2	0.1389
p.A871V	CW-2	large_intestine	COSMIC	PSTPLSE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92547	DNA topoisomerase 2-binding protein 1	DEG_SCF_FBW7_2	859:865	PSTPLSE	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons