DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_COP1_1

Location: 1799:1808

E3 ligase: COP1

DEGRON score: 0.9721

ASA_SCORE: 47.86

COIL: 0.8024

CONS_SCORE: 0.4365

DSS_SCORE: 0.4307

HELIX: 0.0917

FCONS_SCORE: 1.0226

RIG_SCORE: 0.6946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1790T	TCGA-A5-A1OF	UCEC	TCGA	SSSLWGVPTV	DEG_COP1_1	0.0833
p.A1790T	DO42568	UCEC	ICGC	SSSLWGVPTV	DEG_COP1_1	0.0833
p.P1795S	TCGA-AX-A2HA	UCEC	TCGA	SSSLWGVPTV	DEG_COP1_1	0.2222
p.P1795S	DO42504	UCEC	ICGC	SSSLWGVPTV	DEG_COP1_1	0.2222
p.S1791L	DO228650	LICA	ICGC	SSSLWGVPTV	DEG_COP1_1	0.1111
p.T1807K	SIDM00924	Other Solid Cancers	GDSC	SSSLWGVPTV	DEG_COP1_1	0.7306
p.T1807K	ChaGo-K-1	lung	COSMIC	SSSLWGVPTV	DEG_COP1_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_COP1_1	1799:1808	SSSLWGVPTV	COP1	0.9721	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons