DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SCF_FBW7_1

Location: 925:931

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 87.6857

COIL: 0.9364

CONS_SCORE: 0.3316

DSS_SCORE: 0.6626

HELIX: 0.0494

FCONS_SCORE: 1.0798

RIG_SCORE: 0.6281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A940V	DO222842	COCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.0833
p.M940L	DO229016	COCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.0833
p.T927I	DO50364	ESAD	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.7078
p.Q915P	DO49663	LIAD	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.0556
p.M940K	DO46376	OV	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.0833
p.P929S	DO229462	SKCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.6752
p.P931H	DO37440	SKCM	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.7694
p.N924K	DO229221	THCA	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.3056
p.Q925H	DO219773	UCEC	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.7582
p.A939V	DO43290	UCEC	ICGC	LPTPMTS	DEG_SCF_FBW7_1	0.2222
p.S933L	SIDM01175	Other Sarcomas	GDSC	LPTPMTS	DEG_SCF_FBW7_1	0.2778
p.S933L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LPTPMTS	DEG_SCF_FBW7_1	0.2778
p.S933L	ACH-002309	Sarcoma	CCLE	LPTPMTS	DEG_SCF_FBW7_1	0.2778
p.S933L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	0.2778
p.S933L	SW684	soft_tissue	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	0.2778
p.E922K	SIDM01619	Endometrial Carcinoma	GDSC	LPTPMTS	DEG_SCF_FBW7_1	0.25
p.E922K	ACH-000984	Endometrial/Uterine Cancer	CCLE	LPTPMTS	DEG_SCF_FBW7_1	0.25
p.R921H	ACH-000989	Colon/Colorectal Cancer	CCLE	LPTPMTS	DEG_SCF_FBW7_1	0.2222
p.R921H	SNU-175	large_intestine	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	0.2222
p.A926P	ACH-001270	Sarcoma	CCLE	LPTPMTS	DEG_SCF_FBW7_1	0.7503
p.A933V	ACH-001703	Lymphoma	CCLE	LPTPMTS	DEG_SCF_FBW7_1	0.2778
p.A933V	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPMTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SCF_FBW7_1	925:931	LPTPMTS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons