DegronMD

Uniprot ID: Q9UPQ9

Source protein: Trinucleotide repeat-containing gene 6B protein

Source gene: TNRC6B

Class: DEG_SPOP_SBC_1

Location: 232:236

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 83.94

COIL: 0.9464

CONS_SCORE: 0.288

DSS_SCORE: 0.6726

HELIX: 0.0362

FCONS_SCORE: 0.9867

RIG_SCORE: 0.5711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q246R	TCGA-CD-A4MG	STAD	TCGA	PGSTT	DEG_SPOP_SBC_1	0.0556
p.Q246R	DO48009	STAD	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.N237Y	DO228946	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.C245F	DO229034	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.T230S	SIDM00845	Burkitt's Lymphoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	SIDM00461	Acute Myeloid Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	SIDM01519	Head and Neck Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	ACH-000992	Head and Neck Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	S-117	soft_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.T230S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.M246T	ACH-001369	Ovarian Cancer	CCLE	PGSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with TNRC6B mutations

All proteins holding degron of PGSTT