DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 3292:3296

E3 ligase: SPOP

DEGRON score: 0.8894

ASA_SCORE: 80.14

COIL: 0.8204

CONS_SCORE: 0

DSS_SCORE: 0.7391

HELIX: 0.0092

FCONS_SCORE: 0

RIG_SCORE: 0.6014

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3293S	DO229486	LAML	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO228912	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO229053	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO229062	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO229006	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO229218	THCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO229232	THCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.G3293S	DO229089	THCA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.5882
p.T3286M	DO229505	LAML	ICGC	PGSTT	DEG_SPOP_SBC_1	0.1667
p.A3306T	DO229030	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.A3306T	DO229056	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.V3300F	DO229041	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.2222
p.G3293D	DO229063	LICA	ICGC	PGSTT	DEG_SPOP_SBC_1	0.6087
p.T3291N	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PGSTT	DEG_SPOP_SBC_1	0.3056
p.P3283T	SNU-423	liver	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.H3287L	CHP-126	autonomic_ganglia	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1944
p.R3294H	NCI-H1963	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8244
p.R3294H	TE-441-T	soft_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.8244
p.L3292F	TE-441-T	soft_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6981
p.L3292F	NCI-N87	stomach	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6981
p.L3292F	HeLa	cervix	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6981
p.L3292F	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6981
p.L3292F	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6981
p.L3292F	NCI-H1963	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6981
p.P3292L	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292L	CAL-120	breast	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292L	OVCAR-5	ovary	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292L	SNB75	central_nervous_system	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292L	DBTRG-05MG	central_nervous_system	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292L	SW684	soft_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292L	OAW-42	ovary	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.7582
p.P3292S	NCI-H1734	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.6752
p.S3285P	SK-GT-4	oesophagus	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1389
p.S3285P	LN-18	central_nervous_system	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.1389
p.P3298R	HT-144	skin	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.R3282Q	CP67-MEL	skin	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.R3282Q	SK-N-FI	autonomic_ganglia	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0556
p.S3298L	TE-441-T	soft_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778
p.P3283S	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.0833
p.P3298S	SW1271	lung	COSMIC	PGSTT	DEG_SPOP_SBC_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of PGSTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35452	Homeobox protein Hox-D12	DEG_SPOP_SBC_1	147:151	PGSTT	SPOP	0.9966	More...
Q13263	Transcription intermediary factor 1-beta	DEG_SPOP_SBC_1	510:514	PGSTT	SPOP	0.9961	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	537:541	PGSTT	SPOP	0.9681	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6153:6157	PGSTT	SPOP	0.988	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	465:469	PGSTT	SPOP	0.9562	More...
Q9H5V8	CUB domain-containing protein 1	DEG_SPOP_SBC_1	286:290	PGSTT	SPOP	0.9952	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	268:272	PGSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	624:628	PGSTT	SPOP	0.9451	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	680:684	PGSTT	SPOP	0.8958	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	708:712	PGSTT	SPOP	0.5911	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	954:958	PGSTT	SPOP	0.8891	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1066:1070	PGSTT	SPOP	0.9881	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1232:1236	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1512:1516	PGSTT	SPOP	0.9131	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1679:1683	PGSTT	SPOP	0.8675	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1735:1739	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1763:1767	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2037:2041	PGSTT	SPOP	0.8859	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2149:2153	PGSTT	SPOP	0.9256	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2315:2319	PGSTT	SPOP	0.8431	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2623:2627	PGSTT	SPOP	0.8231	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2789:2793	PGSTT	SPOP	0.9047	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3069:3073	PGSTT	SPOP	0.8831	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3236:3240	PGSTT	SPOP	0.9504	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3292:3296	PGSTT	SPOP	0.8894	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3594:3598	PGSTT	SPOP	0.8534	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3706:3710	PGSTT	SPOP	0.9783	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3872:3876	PGSTT	SPOP	0.9192	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4152:4156	PGSTT	SPOP	0.876	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4319:4323	PGSTT	SPOP	0.9707	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4403:4407	PGSTT	SPOP	0.765	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4677:4681	PGSTT	SPOP	0.8675	More...
Q9ULH0	Kinase D-interacting substrate of 220 kDa	DEG_SPOP_SBC_1	1401:1405	PGSTT	SPOP	0.9945	More...
Q9UPQ9	Trinucleotide repeat-containing gene 6B protein	DEG_SPOP_SBC_1	232:236	PGSTT	SPOP	0.9955	More...